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Year 2011 Vol. 19 No 5

GENERAL AND SPECIAL SURGERY

M.I. KUGAEV, I.V. SAMSONOVA, V.A. KLOPOVA, I.A. BEKHTEREVA, A.E. DOROSEVICH

INTERCONNECTION OF THE NERVOUS TISSUE LESION AND FIBROUS CHANGES IN THE PANCREAS HEAD WITH PAIN SYNDROME AND LIFE QUALITY OF PATIENTS AT CHRONIC PANCREATITIS

Objectives. To study the interconnection of the nervous tissue lesion in the head of the pancreas with the degree of fibrous changes as well as with the level of pain syndrome and life quality of patients with chronic pancreatitis (CP).
Methods. 37 patients with CP were examined in whom duodenum saving resection of the pancreas head was performed. The visual analogous scale (VAS) was used to evaluate the intensiveness of the pain syndrome; the questionnaire SF-36 was applied to study life quality. The area of the histological preparation, the area of each nervous structure, the number of nerves and total area of the nervous tissue were evaluated at the microscopic research.
Results. The area of the nervous tissue was reliably smaller at the 1st degree of fibrosis in comparison with the 2nd and 3rd ones. The area of the nervous tissue at the 2nd and 3rd degrees of fibrosis didnt differ significantly. While comparing the number of nerves depending on the fibrosis area it was found out that the number of nerves differs significantly at the 1st and 3rd degrees of fibrosis. While comparing the 1st and 2nd as well as the 2nd and 3rd these differences were unreliable. While comparing the area median of one nerve, one revealed no dependence on the fibrous changes. The area of the nervous tissue, numbers of nerves, area median of one nerve don, t correlate with the quality life scales as well as they don, t depend on the pain syndrome level.
Conclusions. At chronic pancreatitis the lesion of the nervous tissue in the pancreas head depends on the degree of the fibrous changes. Proportion increase of the nervous tissue area to the pancreas tissue occurs due to the number of the nervous elements increase. The marked character of the pain syndrome and life quality doesn, t depend on the nervous tissue lesion.

Keywords: chronic pancreatitis, pancreas fibrosis, life quality, intensiveness of pain syndrome, nervous tissue area
p. 39 – 45 of the original issue
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