Novosti
Khirurgii
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indexed in Scopus









Year 2012 Vol. 20 No 3

GENERAL AND SPECIAL SURGERY

D.A. KLUIKO 1, V.E. KORIK 1, S.A. ZHIDKOV 2

CITOFLAVIN APPLICATION IN COMPLEX TREATMENT OF ACUTE PANCREATITIS

EE Belarusian State Medical University 1,
Military medical administration of the Ministry of defense 2, Minsk,
The Republic of Belarus

Objectives. To improve treatment results of acute pancreatitis, specifically to study the effect of citoflavin on the duration of the disease, blood parameters and possibility of complications.
Methods. The research was carried out in two groups of patients with acute pancreatitis, each group numbering 15 patients. In the experimental group the preparation citoflavin was intravenously administered in the volume of 10 ml diluted on 400 ml of 0,9% sodium chloride solution b.i.d. during 5-10 days. The control group of patients were obtaining a standard treatment. The effect of the medicament therapy was studied on the 5th day after the onset of the preparations application. Direct percutaneous oximetry to estimate the tissue respiration parameters in the anterior abdominal wall skin was used in the diagnostic complex.
Results. Use of antioxidants and antihypoxants is able to normalize the rates of respiratory activity, in particular, the level of oxidative status violations as well as to reduce the level of hypoxia in the pancreatic tissue and, consequently, in the skin of the anterior abdominal wall, which are registered by the direct oximetry.
Conclusions. Application of citoflavin in the treatment of acute pancreatitis contributes to the restoration of oxidative status, reduction of tissue hypoxia and reduces the duration of hospital stay by 2 times.

Keywords: acute pancreatitis, oximetry, conservative treatment, antioxidants, citoflavin
p. 22 27 of the original issue
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Address for correspondence:
220034, Respublika Belarus', g. Minsk, ul. Azgura, 4, UO Belorusskii gosudarstvennyi meditsinskii universitet, voenno-meditsinskii fakul'tet, kafedra voenno-polevoi khirurgii,
e-mail: kluiko@list.ru,
Kluiko Dmitriy Aleksandrovich
Information about the authors:
Kluiko D.A., Major of Medical Service, a Graduate Student of the Chair Of Military Field Surgery of the Military Medicine Faculty of EE "Belarusian State Medical University."
Korik V.E., Candidate of Medical Sciences, Associate Professor, Colonel of Medical Service, Head of Military Field Surgery Chair of the Military Medicine Faculty of EE "Belarusian State Medical University."
Zhidkov S.A., Doctor of Medical Sciences, Professor, Colonel of Medical Service, the Chief of Military Medical Department of the Ministry of Defense of the Republic of Belarus.
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