Novosti
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Year 2012 Vol. 20 No 4
ONCOLOGY
A.O. KHORAU, K.N. UGLANICA
EFFICACY ESTIMATION OF COMBINED USE OF NEOADJUVANT POLYCHEMOTHERAPY AND INTRAVENOUS LASER IRRADIATION OF THE BLOOD IN PATIENTS WITH LOCALLY ADVANCED BREAST CANCER
EE “Grodno State Medical University”
The Republic of Belarus
Objectives. To evaluate the immediate results of treatment at the combined use of the neoadjuvant polychemotherapy and intravenous laser irradiation of the blood in patients with locally advanced breast cancer.
Methods. 101 primary patients with locally advanced breast cancer were included in the research. In the main group (49 patients) – neoadjuvant polychemotherapy was used in combination with intravenous laser irradiation of the blood. In the comparison group (52 patients) – only neoadjuvant chemotherapy was carried out. The efficacy of treatment and side effects were evaluated.
Results. The objective effect in the comparison group made up 55,8%, while in the study group – 73,5%. There were 7 (13,5%) cases of complete clinical regression in the comparison group, in the study group– 12 (24,5%). The complete morphological regression in the comparison group was reported in 2 (4,3%) of observations; in the study one – in 9 (20,0%).
The side effects of treatment were more common in the comparison group. Post therapeutic changes of the III-IV degree in the study group were revealed in 64,4% cases, while in the comparison group – in 38,6% of cases. Leucopenia of the I-II degree in the study group was observed in 10 cases (20,4%), in the comparison group – in 25 (48,1%) of cases. Leucopenia (III degree) was registered in 2 (4,1%) of patients of the study group and in 7 (13,5%) patients of the comparison group. In 3 patients (5,8%) of the comparison group the cardiac dysfunction was observed. The cases of nausea and vomiting (I-II grade) have been reported significantly rare (42,7%) in the study group.
In the main group one observed neither nausea nor vomiting (III degree) versus 5 such cases in the comparison group.
Conclusions. The use of neoadjuvant polychemotherapy and intravenous laser irradiation of the blood in patients with locally advanced breast cancer is a reasonable and effective method of preoperative treatment.
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230009, Respublika Belarus, Grodno, ul. Gorkogo, d. 80, UO «Grodnenskiy gosudarstvennyiy meditsinskiy universitet», kafedra onkologii,
e-mail: anti-11@yandex.ru,
Horov Anton Olegovich
Khorov A.O., Assistant of the Oncology Chair of EE “Grodno State Medical University”.
Uglyanitsa K.N., Doctor of Medical Sciences, Professor, Head of the Oncology Chair of EE “Grodno State Medical University”.
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