Novosti
|
This journal is indexed in Scopus |
|---|
Year 2013 Vol. 21 No 5
EXPERIMENTAL SURGERY
A.P. TRUKHAN, S.A. ZHIDKOV, V.E. KORIK, T.A. LETKOVSKAYA, A.S. ZHIDKOV, D.G. TERESHKO
THE INFLUENCE OF LIMB COMPRESSION FORCE ON THE EXPRESSION OF MORPHOLOGICAL CHANGES DURING CRUSH SYNDROME
EE "Belarusion State Medical University"
The Republic of Belarus
Objectives. To determine the influence of different force of the limb compression on the severity of changes in the internal organs during crush syndrome.
Methods. 15 guinea pigs were subjected to the research. Crush syndrome was modeled using the device of adjustable compression (DAC-1). Depending on the compression force the animals were divided into three groups: 1 group (5 animals) – 10 kg/cm2, 2 group (5 animals) – 25 kg/cm2, 3 group (5 animals) – 75 kg/cm2. The morphological analysis of the tissues was carried out on the muscle of the compressed limb, kidney, liver, lung and heart.
Results. The expression of morphological changes in the muscles and internal organs was in direct proportion from the compression force of the limb and duration of post-compression period. In the first group combined with the damage of the limb muscle the changes in the kidney with slight alterations in other internal organs have been observed. In the second group the more pronounced morphological changes both in the damaged limb and in the internal organs have been noted. This became the basis of multiple organ dysfunctions and resulted in death of the animals on the first day of early post-compression period. The third group of animals died during the compression period. The cause of death was an expressed traumatic shock confirmed by corresponding changes in the internal organs.
Conclusions. The specific changes at the crush syndrome occur not only in the limb muscles but also in the internal organs. Knowledge of these features is the basis for crush syndrome treatment.
- Tsybuliak GN. Obshchaia khirurgiia povrezhdenii [General surgery of damages]. Rukovodstvo dlia vrachei. Saint-Petersburg, RF: Gippokrat, 2005. 648 p.
- Rudaev VI, Krichevskii AL, Galeev IK. Ostraia ishemicheskaia travma miagkikh tkanei v usloviiakh chrezvychainykh situatsii [Acute ischemic injury of soft tissues in emergency situations]. Kemerovo. 1999. 360 p.
- Garkavi AV. Sindrom dlitel'nogo sdavleniia miagkikh tkanei konechnostei [Crush syndrome of soft tissues of the extremities]. Med pomoshch'. 2000;(2):23–28.
- Scharman EJ, Troutman WG. Prevention of kidney injury following rhabdomyolysis: a systematic review. Ann Pharmacother. 2013 Jan;47(1):90-105.
- Nechaev EA, Revskii AK, Savitskii GG. Sindrom dlitel'nogo sdavleniia [Crush syndrome: rukovodstvo dlia vrachei. Moscow, RF: Meditsina, 1993. 208 p.
- Sever MS, Vanholder R. Management of crush victims in mass disasters: highlights from recently published recommendations. Clin J Am Soc Nephrol. 2013 Feb;8(2):328-35.
- Speck K, Schneider BS, Deashinta N. A rodent model to advance the field treatment of crush muscle injury during earthquakes and other natural disasters. Biol Res Nurs. 2013 Jan;15(1):17-25.
- Murata I, Ooi K, Sasaki H, Kimura S, Ohtake K, Ueda H, Uchida H, Yasui N, Tsutsui Y, Yoshizawa N, Hirotsu I, Morimoto Y, Kobayashi J. Characterization of systemic and histologic injury after crush syndrome and intervals of reperfusion in a small animal model. J Trauma. 2011 Jun;70(6):1453-63.
- Trukhan AP, Zhidkov SA, Korik VE, Kiselev MG, Es'man GA, Zhidkov AS, Tereshko DG. Eksperimental'noe modelirovanie sindroma dlitel'nogo sdavleniia [Experimental modeling of crush syndrome].Khirurgiia. Vostochn Evropa. 2013;(1):70–75.
220034, Respublika Belarus', g. Minsk, ul. Azgura, d. 4, UO Belorusskii gosudarstvennyi meditsinskii universitet, voenno-meditsinskii fakul'tet, kafedra voenno-polevoi khirurgii
e-mail: aleksdoc@yandex.ru,
Trukhan Aleksei Petrovich
Trukhan A.P. PhD, an associate professor of military field surgery of the Faculty of Military Medicine of EE "Belarusian State Medical University".
Zhidkov S.A. MD, professor of military field surgery of the Faculty of Military Medicine of EE "Belarusian State Medical University".
Korik V.E. PhD, an associate professor, a head of the chairt of military field surgery of the Faculty of Military Medicine of EE "Belarusian State Medical University".
Letkovskaya T.A. PhD, an associate professor of the chair of pathological anatomy of EE "Belarusian State Medical University".
Zhidkov A.S. A clinical ordinator of military field surgery of the Faculty of Military Medicine of EE "Belarusian State Medical University".
Tereshko D.G. A 6th year student of military field chair of the Faculty of Military Medicine of EE "Belarusian State Medical University".
Article in the .pdf format
