Novosti
Khirurgii

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Year 2014 Vol. 22 No 6

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

V.F. KULIKOVSKY 1, S.V. SHKODKIN 1, Y.R. KOLOBOV 1, V.P. BONDAREV 2

EXPERIMENTAL STUDY OF BIOLOGICAL AND BIOMECHANICAL COMPATIBILITY OF NANOSTRUCTURED SPIRAL STENT

FSAEE HPE “Belgorod State National Research University”1
RSME “Kursk Regional Pathologic-anatomic Office” 2
The Russian Fedreratin

Objectives. To study the effect of spiral mechanical properties of nanostructured spiral stent on indicators of biological and biomechanical compatibility and the possibility of its atraumatic removal through the wall of a hollow organ.
Methods. The mechanical properties of the intestinal tube (5 animals) and implantation of the esophageal stents (40 animals) were studied on Wistar rats. Wherein the titanium nickelide spiral stent was implanted in the esophagus in one half, a spiral prolene stent with the same geometrical parameters without spiral part to remove. On the 14th and 30th days after stent implantation the microcirculatory disorders in the wall of the stented abdominal esophagus have been studied using laser Doppler flowmetry as well as the peritoneal inflammatory response and the stomach impermeability after stent removal.
Results. The differences in the mechanical properties of the studied devices depended on the severity of the submucosal and circular muscle layer have been revealed. The quantitative values of Young’s elasticity modulus and tensile strength had stereotyped indices; the last was determined by a species of biological object. Cytology of the visceral peritoneum throughout the experiment was characterized by greater severity of inflammatory changes in the control group. The microcirculatory disturbances have been registered in all animals in the wall of the stented esophagus, but up to the 14th day of the experiment in the control group the perfusion reduction significantly differed from the main group: 371,8±94,5 and 606,9±52,6 PU, respectively (p<0,05). Morphological study on both control intervals showed the greater severity of inflammatory infiltration, hypertrophic and sclerotic changes in the control.
Conclusion. Experimental study of the stented esophagus of the laboratory Wistar rats has revealed microcirculatory disorders, inflammatory changes and the incidence of perforation of the esophageal wall with identical geometric characteristics are considered to be associated with mechanical rigidity of stent spiral.

Keywords: medical implants, stent, biocompatibility
p. 654-664 of the original issue
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Address for correspondence:
308015, Rossiyskaya Federatsiya,
g. Belgorod, ul. Pobedyi, d. 85,
Kafedra gospitalnoy khirurgii
FGAOU VPO «Belgorodskiy gosudarstvennyiy
natsionalnyiy issledovatelskiy universitet», tel. 79103207071,
e-mail: shkodkin-s@mail.ru,
Shkodkin Sergey Valentinovich
Information about the authors:
Kulikovsky V.F. MD, professor, director of medical institute, a head of the hospital surgery chair of FSAEE HPE “Belgorod State National Research University”.
Shkodkin S.V. PhD, associate professor of the hospital surgery chair of FSAEE HPE “Belgorod State National Research University”.
Kolobov Y.R. Dr. Sci., professor, a head of the scientific, educational and innovation center "Nanostructured Materials and Nanotechnology" of FSAEE HPE “Belgorod State National Research University”.
Bondarev V.P. A head of the department of pediatric pathology and infectious pathology of RSME “Kursk regional pathologic and anatomic office”.
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