Novosti
Khirurgii

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Year 2017 Vol. 25 No 4

REVIEWS

K.A. BATSIKOV, M.M. MAGOMEDOV

REPERFUSION SYNDROME IN ACUTE INTESTINAL OBSTRUCTION

FSBEE HE “Dagestan State Medical University”,
Makhachkala,
The Russian Federation

The paper aims to present the review of literature on acute intestinal obstruction in case of the reperfusion syndrome. Ischaemia reperfusion syndrome is a complex pathological process characterized by initial restriction of blood supply to the organ followed by subsequent restoration of blood flow, has a significant impact on cell membrane integrity and activation of the lipid peroxidation process. Resulted from the cell membrane permeability, excessive cytokine and proteolytic enzymatic activity leads to the dysfunction of the kallikrein-kinin and hemostasis system and thus plays an important role in the mechanism of the perfusion development. Ischemia/reperfusion syndrome is characterized by mostly nonspecific abnormalities in coagulation profile, general and biochemical analysis. However, dynamics of the syndrome can be based on changing the levels of more specific markers that are not routinely assessed yet, probably due to expensive reagents. Presently, there is no uniform tactics of treatment and prevention of reperfusion syndrome despite the attempts to treat patients by hypothermia, antioxidants, protease inhibitors, and anticoagulants. Therefore, basing on the literature data it should be noteworthy that early diagnostics and treatment of reperfusion syndrome still remain difficult not completely solved issue.

Keywords: acute intestinal obstruction, reperfusion syndrome, lipid peroxidation, hemostasis system, oxidative distress, treatment, prevention, endothelial dysfunction
p. 404-411 of the original issue
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Address for correspondence:
367000, Russian Federation,
Republic of Dagestan, Makhachkala,
Pirogov st., 3, FSBEE HE "Dagestan State
Medical University", Department of Surgery
Tel.: 79282308646,
E-mail: muxuma@mail.ru; hairula_dgma@mail.ru.
Muhuma M. Magomedov
Information about the authors:
Magomedov M.M. MD, Professor of department of the advanced training and retraining of the medical specialists.
Batsikov K.A. Post-graduate student of department of the advanced training and retraining of the medical specialists, FSBEE HE “Dagestan State Medical University”.
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