Novosti
Khirurgii

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Year 2018 Vol. 26 No 3

REVIEWS

A.I. CHERNOOKOV 1, A.YU. BOZHEDOMOV 2, A.A. ATAYAN 1, 2, E.N. BELYKH 1, E.S. SYLCHUK 3, E.O. KHACHATRYAN 1

NEW BIOMARKERS OF ACUTE MESENTERIC ISCHEMIA

I.M. Sechenov First Moscow State Medical University (Sechenov University) 1,
City Clinical Hospital ¹29 named after N. E. Bauman, Moscow Healthcare Department 2,
Center of Phlebology 3, Moscow,
The Russian Federation

The acute mesenteric ischemia is one of the most complex problems in the urgent surgery because of the high mortality, the cause of which is late diagnosis. The operation treatment is often provided in the phase of diffuse peritonitis.
This literature review is done in order to identify the most accessible and accurate methods of early diagnosis of the acute mesenteric ischemia.
At present time rather a small number of biomarkers for diagnosing the acute mesenteric ischemia are used, such as α-glutamate-S-transferase, D-dimers, procalcitonin, D-lactate, intestinal fatty acid binding protein (I-FABP), ischemia-modified albumin. According to the literature the highest sensitivity and specificity were found in I-FABP (75-85% and 70-80% respectively), α-glutamate-S-transferase (67.8% and 84.2%), ischemia-modified albumin (94.7% and 86.4%). In addition, expensive and invasive methods are currently used for early diagnosis, such as CT angiography, contrast-enhanced MRI, selective angiography. However, these technologies are not available to all medical institutions.
We should continue further search of various biomarkers and their more widespread introduction to clinical practice in order to solve the problem of early acute mesenteric ischemia diagnostics.

Keywords: acute mesenteric ischemia, biomarkers, diagnostics, mesenteric thrombosis, intestinal fatty acid binding protein (I-FABP)
p. 358-365 of the original issue
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Address for correspondence:
111020, The Russian Federation,
Moscow, Hospital Square, 2,
City Clinical Hospital ¹29
named after N. E. Bauman,
Moscow Healthcare Department,
Endovascular Surgery Unit,
Tel. office: +7(499) 263-21-30,
e-mail: alecso_84@mail.ru,
Aleksey Yu. Bozhedomov
Information about the authors:
Chernookov Alexandr I., MD, Professor, Head of the Department of Hospital Surgery ¹2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation. http://orcid.org/0000-0003-3124-4860
Bozhedomov Aleksey Yu., PhD, Surgeon of the Surgical Unit ¹3, City Clinical Hospital ¹29 named after N. E. Bauman, Moscow Healthcare Department, Moscow, Russian Federation. http://orcid.org/0000-0002-8544-932X
Atayan Andrey A., PhD, Assistant of the Department of Hospital Surgery ¹2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Surgeon of the Endovascular Surgery Unit, City Clinical Hospital ¹29 named after N. E. Bauman, Moscow Healthcare Department, Moscow, Russian Federation.
http://orcid.org/0000-0001-8914-7735
Belyx Elena N., PhD, Associate Professor of the Department of Hospital Surgery ¹2, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
http://orcid.org/0000-0001-5864-7892
Silchuk Evgenii S., PhD, Surgeon, Head of the Lymphology Unit, Center of Phlebology, Moscow, Russian Federation. http://orcid.org/0000-0003-4018-4468
Hachatryan Edita O., Fourth–Year Medical Student, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
http://orcid.org/0000-0003-2636-3945
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