Novosti
Khirurgii

 This journal is
indexed in Scopus
journal cover
android icon Android Applicaion

Year 2018 Vol. 26 No 3

GENERAL & SPECIAL SURGERY

I.S. IVANOV 1, V.I. TEMIRBULATOV 1, 2, M.E. KLETKIN 2, O.A. OKUNEV 1, I.A. IVANOVA 1

CORRELATION OF COLLAGEN TYPE I AND III IN THE SKIN AND LUNGS IN PATIENTS WITH BULLOUS EMPHYSEMA COMPLICATED BY SPONTANEOUS PNEUMOTHORAX

Kursk State Medical University 1,
Kursk regional clinical hospital 2, Kursk
The Russian Federation

Objective. To study the correlation of type I and III collagens of the connective tissue in the skin and lungs in patients with the bullous emphysema complicated by spontaneous pneumothorax and without it.
Methods. A comparative analysis of the content of type I and III collagens in the skin and lung in 32 patients with the lung bullous emphysema complicated by spontaneous pneumothorax and control group (autopsy material from 30 people without obvious pathology of the lungs) was carried out. The study of type I and III collagens in the skin and lungs was carried out using polarization microscopy, which allows revealing the correlation of collagen types in patients of the studied groups.
Results. It has been found out that patients with the bullous emphysema have a significantly lower ratio of type I and III collagens in both the skin and lung preparations in comparison with the control group. A high direct correlation has been registered between the correlation of collagen types of the skin and lungs connective tissue in both groups.
Conclusions. The patients with the bullous emphysema have a significantly lower ratio of type I and III collagens in the skin and lungs. The presence of a high direct correlation between the content of different types of collagen in the skin and lungs, both in the main and control groups, allows identifying the systemic pathology of the connective tissue only by its changes in the skin of patients. Determination of the relative ratio of type I and III collagens in preparations of the skin and lung with the use of polarization microscopy has high informative value in the verification of the bullous emphysema as one of the manifestations of connective tissue dysplasia.

Keywords: bullous emphysema, spontaneous pneumothorax, collagen type I, collagen type III, polarized microscopy
p. 293-300 of the original issue
References
  1. Vershinina MV, Grinberg LM, Nechaeva GI, Govorova SE, Gershevich VM, Neretin AV, Filatova AS. Spontannyi pnevmotoraks i displaziia soedinitel’noi tkani: fenotipicheskie osobennosti patsientov. Pul’monologiia. 2011;(6):43-47. doi: 10.18093/0869-0189-2011-0-6-43-47 (in Russ.)
  2. Luh SP. Review: Diagnosis and treatment of primary spontaneous pneumothorax. J Zhejiang Univ Sci B. 2010 Oct;11(10):735-44. doi: 10.1631/jzus.B1000131
  3. Beliaeva IV, Stroev IuI, Churilov LP. Pervichnyi spontannyi pnevmotoraks i displaziia soedinitel’noi tkani. Med Al’ians. 2014;(1):43-53. (in Russ.)
  4. Vershinina MV, Nechaeva GI, Grinberg LM, Skripkin DA, Ignat’ev IuT, Govorova SE, Drokina OV. Displaziia soedinitel’noi tkani v geneze bulleznoi emfizemy: ostanetsia li «pervichnym» pervichnyi spontannyi pnevmotoraks? Lechashchii Vrach. 2012;(9):14. https://www.lvrach.ru/2012/09/15435522 (in Russ.)
  5. Rokicki W, Rokicki M, Wojtacha J, Filipowski M, Dzejlili A, Czyzewski D. Is it possible to standardize the treatment of primary spontaneous pneumothorax? Part 1: etiology, symptoms, diagnostics, minimally invasive treatment. Kardiochir Torakochirurgia Pol. 2016 Dec; 13(4): 322-27. Published online 2016 Dec 30. doi: 10.5114/kitp.2016.64874
  6. Tsai TM, Lin MW, Li YJ, Chang CH, Liao HC, Liu CY, Hsu HH, Chen JS. The size of spontaneous pneumothorax is a predictor of unsuccessful catheter drainage. Sci Rep. 2017;7:181. Published online 2017 Mar 15. doi: 10.1038/s41598-017-00284-8
  7. Vershinina MV, Nechaeva GI, Grinberg LM, Govorova SE, Gershevich VM, Neretin AV. Retsidiviruiushchii i peremezhaiushchiisia pervichnyi spontannyi pnevmotoraks u patsientov s displaziei soedinitel’noi tkani. Tuberkulez i Bolezni Legkikh. 2012;89(5):15-19. (in Russ.)
  8. Nechaeva GI, Iakovlev VM, Konev VP, Druk IV, Morozov SL. Displaziia soedinitel’noi tkani: osnovnye klinicheskie sindromy, formulirovka diagnoza, lechenie. Lechashchii Vrach. 2008;(2):22-28. https://www.lvrach.ru/2008/02/4828890/ (in Russ.)
  9. Smirnovà GO, Manturova NE, Topchieva GV, Stupin VA. Aging skin mechanisms and collagen ratio I/III types in prediction of aesthetic surgery. Fundam Issledovaniia. 2012;(7-1):190-94. https://www.fundamental-research.ru/ru/article/view?id=30065 (in Russ.)
  10. Malkusch W, Rehn B, Bruch J. Advantages of Sirius Red staining for quantitative morphometric collagen measurements in lungs. Exp Lung Res. 1995 Jan-Feb;21(1):67-77. doi: 10.3109/01902149509031745.
  11. Tseluyko SS, Krasavina NP. Immunocytochemical characteristic of bronchi bioptats conjunctive tissue collagen types in patients with respiartory apparatus dysplasia. Biul Fiziologii i Patologii Dykhaniia. 2010;(38):36-42. https://cyberleninka.ru/article/n/immunotsitohimicheskaya-harakteristika-tipov-kollagena-soedinitelnoy-tkani-bioptatov-bronhov-bolnyh-s-displaziey-organov-dyhaniya (in Russ.)
  12. Vershinina MV, Grinberg LM, Nechaeva GI, Filatova AS, Neretin AV, Khomenia AA, Govorova SE. Pervichnyi spontannyi pnevmotoraks i displaziia soedinitel’noi tkani: kliniko-morfologicheskie paralleli. Pul’monologiia. 2015;25(3):340-49. doi: 10.18093/0869-0189-2015-25-3-340-349 (in Russ.)
  13. Pimenov LT, Smetanin MYu, Remnyakov VV, Suslonova SV. Primary spontaneous pneumothorax as a manifestation of connective tissue dysplasia (literature review). CardioSomatika. 2014;(2):43-46. http://www.rosokr.ru/magazine/KS-2014-2.pdf (in Russ.)
  14. Veligotskii NN, Komarchuk VV, Komarchuk EV, Kasumba K. Khirurgicheskoe lechenie gryzh na fone displazii soedinitel’noi tkani. Ukr Zhurn Khirurgii. 2011;(3):236-239. http://www.ujs.dsmu.edu.ua/journals/2011-03/2011-03.pdf (in Russ.)
  15. Ivanov IS, Lazarenko VA, Ivanov SV, Goryainova GN, Ivanov AV, Tarabrin DV, Litvyakova MI. Correlation of collagen type I and III in the skin and aponeurosis in patients with ventral hernias. Novosti Khirurgii.
    2013; 21(3):33-36. doi: 10.18484/2305-0047.2013.3.33 (in Russ.)
Address for correspondence:
305007, The Russian Federation,
Kursk, Sumskaya Str., 45 à,
Kursk Regional Clinical Hospital,
Thoracic Surgery Unit,
Tel.: +7 903 875-30-58,
e-mail: kletkin-max@mail.ru,
Maxim E. Kletkin
Information about the authors:
Ivanov Ilia S., MD, Professor of the Department of Surgical Diseases ¹1, Kursk State Medical University, Kursk, Russian Federation.
https://orcid.org/0000-0003-4408-961X
Temirbulatov Vladimir I., MD, Professor of the Department of Surgical Diseases FPED, Kursk State Medical University, Head of the Thoracic Surgery Unit, Kursk Regional Clinical Hospital, Kursk, Russian Federation.
https://orcid.org/0000-0003-3757-924X
Kletkin Maxim E., Physician of the Thoracic Surgery Unit, Kursk Regional Clinical Hospital, Kursk, Russian Federation.
https://orcid.org/0000-0003-3886-5272
Okunev Oleg A., PhD, Assistant of the Department of Surgical Diseases ¹1, Kursk State Medical University, Kursk, Russian Federation.
https://orcid.org/0000-0002-2298-1546
Ivanova Inna A., PhD, Associate Professor of the Department of Clinical Immunology and Allergology, Kursk State Medical University, Kursk, Russian Federation. https://orcid.org/0000-0001-5175-6586
Contacts | ©Vitebsk State Medical University, 2007-2023