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Khirurgii

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Year 2020 Vol. 28 No 3

REVIEWS

T.A. JARKENOV 1, O.G. SKIPENKO 2, M.N. ZHUMABAEV 1, S.T. ZAIROVA 3, N.A. AKATAEV 1, D.B. YESSENBAEV 1, M.M. MUKUSHEV 1, K.ZH. NURMANOV 1, M.E. BALSHAMBAEV 1

THE ASSOCIATION OF TUMOR NECROSIS FACTOR-α GENE POLYMORPHISM WITH THE SEVERITY OF ACUTE PANCREATITIS: A SYSTEMATIC REVIEW

West Kazakhstan Marat Ospanov State Medical University 1, Aktobe,
The Republic of Kazakhstan
Hepato-Pancreato-Biliary Association of Commonwealth of Independent States 2, Moscow,
The Russian Federation,
Military Institute of Air Defense Named after T.J. Begeldinov 3, Aktobe,
The Republic of Kazakhstan

Objective. The performance of a systematic review of the current literature and meta-analysis to provide the more precise estimations of the association between TNF-α gene polymorphism with the development and severity of acute pancreatitis (AP).
Methods. A systematic review, searching the Medline and Web of Science databases revealed the relevant researches. The analysis based on ten molecular genetic case-control studies of the TNF-α promoter in patients with acute pancreatitis (n=1660) and healthy volunteers (n=1618).
Results. A systematic review showed discrepant results. In three studies the association of functionally significant polymorphism -308G> A in the TNF gene promoter with a severe form of AP, development SIRS and MODS have been established. The association of -308 G / A polymorphism of the TNF gene with the risk of a developing of moderate form of acute non-biliary pancreatitis was identified in one study. In other studies the association of TNF gene polymorphism with the severity of AP was not confirmed.
Conclusions. The presented genetic studies of the TNF-α promoter at acute pancreatitis manifested the controversal results.

Keywords: acute pancreatitis, clinical course, molecular genetic studies, tumor necrosis factorα, genetic polymorphism
p. 309-317 of the original issue
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Address for correspondence:
030019, Republic of Kazakhstan,
Aktobe, Maresyev str., 68,
West Kazakhstan Marat Ospanov Medical University, Surgical Diseases In the absenc No 1,
tel. +7 7132 544297,
e-mail: timurjarkenov@gmail.com,
Timur A. Jarkenov
Information about the authors:
Jarkenov Timur A.,MD, Professor of the Surgical Diseases Department No 1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.
https://orcid.org/0000-0003-4579-6412
Skipenko Oleg G., MD, Professor, Member of Board of Hepato-Pancreato-Biliary Association of Commonwealth of Independent States, Moscow, Russian Federation.
https://orcid.org/0000-0002-4192-9620
Zhumabaev Marat N., PhD, Associate Professor, Head of the Surgical Diseases Department No1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.
https://orcid.org/0000-0002-5092-6034
Zairova SauleT., PhD, Military Institute of Air Defense Named after T.J. Begeldinov, Aktobe, Republic of Kazakhstan.
https://orcid.org/0000-0003-3734-6884
Akataev Nagashybai A., PhD, Professor of the Surgical Diseases Department No1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.
https://orcid.org/0000-0001-8964-5152
Yessenbaev Daulet B., Assistant of the Surgical Diseases Department No1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.
https://orcid.org/0000-0001-9777-0594
Mukushev Manas M., PhD, Associate Professor of the Surgical Diseases Department No1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan
https://orcid.org/0000-0003-1811-3276
Nurmanov Kairat Zh., Assistant of the Surgical Diseases Department No1, West Kazakhstan Marat Ospanov Medical University), Aktobe, Republic of Kazakhstan.
https://orcid.org/0000-0003-1422-7524
Balshambayev Madi E., Assistant of the Surgical Diseases Department No1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.
https://orcid.org/0000-0002-0206-1769
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