Novosti
Khirurgii
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Year 2006 Vol. 14 No 2

I.P. SHTURICH, V.N. SHILENOK, L.N. KIRPICHENOK

ACTIVITY OF PROTEOLYTIC PROCESSES IN THE BLOOD SERUM AND PERITONEAL LIQUID AT DIFFERENT STAGES OF PERITONITIS

The research results of proteolytic processes activity in the blood serum and peritoneal liquid in 42 patients at different stages of peritonitis are presented in the article. It has been found out that in case of peritonitis, changes in activity and/or in components content of the proteolysis system in the blood serum and peritoneal liquid occur depending on the stage of peritonitis. In the blood serum general proteolytic activity is subjected to the most significant changes; at the stage of polyorganic insufficiency it 13, 4 times increases in comparison with the toxic stage. In the peritoneal liquid a1- proteinase inhibitor is the most labile which decreases sharply at the toxic stage – in 3, 2 times in comparison with the reactive stage and then it rises again. Increase of general proteolytic activity in the blood serum of more than 100 nmole/lHs is the criteria of transferring from the toxic stage of peritonitis to the stage of the polyorganic insufficiency. Decrease of a1- proteinase inhibitor content in the peritoneal liquid less than 0, 4 g/l is the criteria of transferring of the reactive peritonitis stage to the toxic one. Not only the liver but also the blood cells – monocytes, lymphocytes and segmental- nucleus neutrophils are the source of proteinase and its endogenic inhibitors. Different cells participate at different stages of peritonitis according to the revealed correlations.

Keywords: peritonitis, stages of peritonitis, proteolytic activity, polyorganic insufficiency
p. 13 - 21 of the original issue
References
  1. Веремеенко, К.Н. Протеолиз в норме и при патологии / К.Н. Веремеенко, О.П. Голобородько, А.И. Кизим. – Киев: Здоров’я, 1988. – 199 с.
  2. Косинец, А.Н Протеиназы и их ингибиторы в гнойной хирургии и онкологии / А.Н. Косинец, Л.Н. Кирпиченок. – Витебск, 2003. – 410 с.
  3. Хватов, В.Б. Ускоренный метод определения основных ин-гибиторов протеиназ в плазме крови человека: метод. рекомендации / В.Б. Хватов, Т.А. Белова; МЗ РСФСР.– Москва, 1981. – 16 с.
  4. Erlanger, D.F. The preparation and properties of two new chromogenic substates of trypsin / N. Kokowsky, W. Cohen // Arch. Biochem. Biophys. – 1961. – Vol. 95, N 2. – P. 271-278.
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