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Year 2007 Vol. 15 No 1

REVIEWS

GIDRANOVICH A.V.

LIPID METABOLISM AND BREAST CANCER: INFLUENCE OF THE VITAMIN THERAPY

The lipid metabolism plays a considerable role in the pathogenesis of many diseases. Though the greatest scientific material has been obtained by different investigators, there isnТt the ultimate opinion concerning the degree of lipid metabolism mechanisms involvement in the carcinogenesis including the origin and progression of breast cancer. Breast cancer affects women at pre-menopausal age and women at postmenopausal age, who are characterized by the increased levels of LDL cholesterol and the reduced levels of HDL cholesterol. Some investigators draw parallels between metabolic syndrome in the postmenopausal women (obesity, low glucose tolerance, low serum HDL cholesterol, and high serum triglycerides hypertension) and breast cancer. Development of breast cancer results in the changes of metabolic indexes. In the breast cancer patients, dyslipidemia develops and becomes worse, and it leads to high levels of total cholesterol, triglycerides, LDL cholesterol, low HDL cholesterol. Vitamins directly or indirectly participate in lipid metabolism, resulting in lipid metabolism changes during their consumption. One must take this fact into account in individual rehabilitation program development.

Keywords: breast cancer, lipid metabolism, vitamins.
p. 93 - 102 of the original issue
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