Novosti
Khirurgii
This journal is
indexed in Scopus



Year 2008 Vol. 16 No 3

ONCOLOGY

SPIRIDONOV S.V.

REMOTE RESULTS OF THE ADJUVANT THERAPY IN THE PATIENTS WITH NON-SMALL CELL LUNG CANCER WITH METASTASES IN THE MEDIASTINUM LYMPH NODES

Unsatisfactory statistics of the 5-year survival in the stage III of non-small cell lung cancer affecting mediastinal lymph nodes after radical surgery requires searching for new ways of extending patients’ life and clinical recovery. The aim of this study is to compare effectiveness of various schemes of adjuvant polychemotherapy with the usage of Cisplatin and Etoposide (CV) in one case and Navelbine, Cisplatin and Etoposide (NCV) in the other, and adjuvant radiation therapy in the total focal dose of 40 and 50 Gr for the patients with non-small cell lung cancer with metastases in mediastinal lymph nodes, who underwent radical surgeries. It was found out that the most effective adjuvant therapy for the patients with non-small-cell lung cancer of the III-A B stages (N2) is polychemotherapy by the scheme Navelbine-Cisplatin-Etoposide. While using this scheme, the 5-year survival is significantly higher than in case of postoperative radiation therapy application with the total focal dose in 40 Gr and 50 Gr by the scheme Cisplatin and Etoposide.

Keywords: non-small cell lung cancer, adjuvant radiation therapy, adjuvant polychemotherapy
p. 92 – 99 of the original issue
References
  1. Руководство по химиотерапии опухолевых заболеваний / под ред. Н. И. Переводчиковой. – 2-е изд., доп. и перераб. – М.: Практическая медицина, 2005. – 704 с.
  2. Спиридонов, С. В. Отдаленные результаты послеоперационной лучевой терапии у больных немелкоклеточным раком легкого с метастазами в лимфоузлах средостения / С. В. Спиридонов, В. В. Жарков, В. П. Курчин // Новости хирургии. – 2007. – Т. 15, № 3. – С. 16-26.
  3. Жарков, В.В. Комбинированное лечение больных немелкоклеточным раком легкого (НМРЛ) IIIА (N2) cтадии с адъювантной терапией / В. В. Жарков, В. П. Курчин, С. В. Спиридонов // IV съезд онкологов и радиологов СНГ: материалы съезда, Баку, 28 сентябр.-1 октябр. 2006 г. / Министерство здравоохранения Азербайджан. Республики; Азербайджан. мед. ун-т. – Баку, 2006. – С. 109.
  4. Le Chevalier, T. Results of the randomized international adjuvant lung cancer trial (IALT) cisplatin-based chemotherapy versus no chemotherapy in 1867 patients with resected non-small cell lung cancer / T. Le Chevalier // Proc. ASCO. – 2003. – Vol. 22. – P. 2.
  5. Mountain, C. F. Regional lymph node classification for lung cancer staging / C. F. Mountain, C. M. Dresler // Chest. – 1997. – Vol. 111, N 6. – P. 1718-1723.
  6. The epidemiology of non-small cell lung cancer / N. Page [et al.] // Program and abstracts of the American Society of Clinical Oncology 38th Annual Meeting. – 2002. – P. 18-21.
Contacts | ©Vitebsk State Medical University, 2007