Novosti
Khirurgii
This journal is
indexed in Scopus



Year 2009 Vol. 17 No 3

GENERAL AND SPECIAL SURGERY

V.A. PREDKO, A.V. NAUMOV, E.M. DOROSHENKO, R.E. YAKUBTSEVICH, V.V. SPAS, I.A. SHAPEL

HYPERHOMOCYSTEINEMIA CORRECTION AT SEPSIS

Homocystein is one of cytotoxic metabolites formed in case of sepsis. In the given research homocysteine level in healthy people and septic patients is being studied. Homocysteine content has been found out to be twice higher in septic patients than in healthy people. Hemosorption sessions with the use of the biospecific hemosorbent Ovosorb were performed to correct hyperhomocysteinemia. They permitted to decrease homocysteine level up to the normal one. Application of hemosorbtion with the use of the hemosorbent Ovosorb permits to normalize leukocyte content in the blood as well as to reduce the burden of patients state and the treatment duration at the resuscitation department.

Keywords: sepsis, homocysteine, hemosorbtion
p. 80 - 87 of the original issue
References
  1. Methionine metabolism in an animal model of sepsis / A. Semmler [et al.] // Clin. Chem. Lab. Med. 2008. Vol.46. P. 1398-402.
  2. Papatheodorou, L. Vascular oxidant stress and inflammation in hyperhomocysteinemia / L. Papatheodorou, N. Weiss // Antioxid. Redox Signal. 2007. Vol. 9, N 11. P. 1941-1958.
  3. , . . / . . // . 2007. 1. C. 4 -7.
  4. Homocysteinemia: vascular injury and arterial thrombosis / L. Harker [et al.] // N. Engl. J. Med. 1974. Vol. 291. P. 537-43.
  5. Hansrani, M. Homocysteine in myointimal hyperplasia / M. Hansrani, J. Gillespie, G. Stansby // Eur. J. Vasc. Endovasc. Surg. 2000. Vol. 23. P. 3-10.
  6. Rodiono, R. N. The homocysteine paradox / R. N. Rodionov, S. R. Lentz // Arterioscler. Thromb. Vasc. Biol. 2008. Vol. 28, N 6. P. 1031-1033.
  7. Glushchenko, A. V. Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease / A. V. Glushchenko, D. W. Jacobsen // Antioxid Redox Signal. 2007 Vol. 9, N 11. . 1883-1898.
  8. Welch, G. Homocysteine and atherosclerosis / G. Welch, J. Loscalo // New Engl. J. Med. 1998. Vol. 338, N 15. P. 1042-1050.
  9. Jacobsen, D. W. Determinants of hyperhomo-cysteinemia: a matter of nature and nurture / D. W. Jacobsen // Am. J. Clin. Nutr. 1996. Vol. 64, N 4. P. 641-642.
  10. Finkelstein, J. D. The metabolism of homo-cysteine: pathways and regulation / J. D. Finkelstein // Eur. J. Pediatr. 1998. Vol. 157. Suppl. 2. P. S40-S44.
  11. Determination of plasma and serum homocysteine by high-performance liquid chromatography with fluorescence detection / G. Minniti [et al.] // J. Chromatogr A. 1998. Vol. 828, N 1-2. P. 401-405.
  12. Navumau, A. V. Plasma homocysteine levels in pregnant women with birth defects foetuses / A. V. Navumau, M. M. Zolotukhin, A. R. Plotski // Acta Biochem. Pol. 2006. Vol. 53. Suppl. 1. P. 195.
  13. Random generator source [ ]. 2008. : http://www.grsmu.by/show.php?n=134.htm. : 21.02.2009.
  14. Krijt, J. Measurement of homocysteine and other aminothiols in plasma: advantages of using tris(2-carboxyethyl)phosphine as reductant compared with tri-n-butylphosphine / J. Krijt, M. Vackov, V. Kozich // Clin. Chem. 2001. Vol. 47, N 10. P. 1821-1828.
  15. Hyperhomocysteinemia induced by folic acid deficiency and methionine load-applications of a modified HPLC method / P. Durand [et al.] // Clin. Chim. Acta. 1996. Vol. 252, N 1 P. 83-93.
  16. Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cells / K. Schroecksnadel [et al.] // Clin. Exp. Immunol. 2003. Vol. 134, N 1. P. 53-56.
  17. Moderate hyperhomocysteinemia and immune activation / K. Schroecksnadel [et al.] // Curr. Pharm. Biotechnol. 2004. Vol. 5, N 1. P. 107-118.
  18. Aspirin downregulates homocysteine formation in stimulated human peripheral blood mononuclear cells / K. Schroecksnadel [et al.] // Scand. J. Immunol. 2005. Vol. 62, N 2. P. 155-160.
  19. Atorvastatin suppresses homocysteine formation in stimulated human peripheral blood mononuclear cells / K. Schroecksnadel [et al.] // Clin. Chem. Lab. Med. 2005. Vol. 43, N 12. P. 1373-1376.
  20. Elmore, C. L. The many flavors of hyper-homocysteinemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism / C. L. Elmore, R. G. Matthews // Antioxid Redox Signal. 2007. Vol. 9, N 11. P. 1911-1921.
Contacts | ©Vitebsk State Medical University, 2007