Novosti
Khirurgii
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indexed in Scopus



Year 2010 Vol. 18 No 3

EXPERIMENTAL SURGERY

VOLKOVICH T.K., SAMSONOVA I.V.

EXPERIMENTAL MODEL OF THE BACTERIAL KERATITIS

Objective. To work out the experimental model of the bacterial keratitis approximating to the disease development in man according to clinical, cytological and morphological signs.
Methods. The experimental model of the bacterial keratitis was designed on 25 rabbits by means of the sectional trepanation of the cornea with its subsequent being infected with the bacterial suspension Staphylococcus aureus. The impression cytology of the cornea and histological investigation of the cuts of the eye’s anterior segment were performed to evaluate the pathomorphological changes.
Results. The experimental model of the bacterial keratitis was designed with initiation of the inflammatory process of the conjunctiva, the cornea, the iris and the ciliary body; it is proved by the marked necrotic and necrobiotic changes of the eyeball anterior segment structures.
Conclusion. The designed experimental model of the bacterial keratitis according to its clinical, cytological and histological signs approximates the same in man and can be used for further investigation of the inflammatory process pathogenesis of the cornea and for working out new approaches to its conservative and surgical treatment.

Keywords: bacterial keratitis, cornea, inflammatory process, epithelium, regeneration
p. 26 – 31 of the original issue
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Contacts | ©Vitebsk State Medical University, 2007