Novosti
Khirurgii
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indexed in Scopus



Year 2010 Vol. 18 No 5

LECTURES, REVIEWS

GAIN YU.M., KISELYOVA E.P.

PROSPECTS AND POSSIBILITIES OF CELL TRANSPLANTATION AT RESTORING OF EXTENSIVE SOFT TISSUE DEFECTS OF TRAUMATIC ORIGIN

Objectives. To estimate the efficacy of modern treatment techniques of cell transplantation, used to restore the extensive defects of soft tissues at a trauma of various etiology and to determine the most perspective directions for the development of the given technologies in the Republic of Belarus.
Methods. Modern native and foreign literature was analyzed dealing with theoretical aspects as well as clinical experience of application of cell technologies of the regenerative medicine in restoring soft tissues extensive defects of the traumatic origin.
Results. The comparative analysis of native and foreign literature was carried out with the efficacy estimation of the applied cell transplantation techniques in the experiment and in a clinic with the therapeutic aim. One should accept the therapeutic technologies based on the application of mesenchymal stem cells which permit to avoid the main disadvantages linked with the procedure of autologous tissues transplantation as the most perspective direction of substitution of the extensive tissue defects of the traumatic and other origins. The advantages of the given technique are the following: 1) small amount of aspirate containing mesenchymal stem cells obtained from the bone marrow, adipose tissue and other sources can be increased up to necessary amount in the vitro and then used to treat a number of diseases including the substitution of the extensive tissue defects forming as the result of trauma and other pathologies; 2) mesenchymal stem cells can be differentiated in several cell generations, thus giving the possibility to use total cell resource for restoring different tissues in contrast to the principle of healthy tissue intake for restoring their own kind at autologous tissues transplantation; 3) mesenchymal stem cells can be introduced in the biocompatible grafts, transplanted to the places of anatomical defects for further reconstruction of the damaged organ or tissue; 4) treatment of different diseases and traumas with application of mesenchymal stem cells can be autologous and at the same time solve the problems dealing with the immune reaction, vector-borne transmission of pathogens, wear and tear of synthetic materials, allergic reaction to the artificial implants.
Conclusions. Prospects of the regenerative medicine development based on the cellular technologies were and are rather impressive and they continue to attract attention of scientists all over the world. One may suppose that in the nearest future cell transplantation will take its rightful place in the arsenal of treatment for wounds, burns and for restoring a wide range of tissues in the human body.

Keywords: regeneration, stem cells, tissue engineering, burns, transplantation
p. 133 143 of the original issue
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