Novosti
Khirurgii
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indexed in Scopus



Year 2010 Vol. 18 No 5

EXPERIMENTAL SURGERY

USHKEVICH A.L., ZHANDAROV K.N., PROKOPCHIK N.I.

PHOTODYNAMIC THERAPY IN TREATMENT OF ACUTE DESTRUCTIVE PANCREATITIS, PARAPANCREATITIS IN EXPERIMENT

Objectives. To estimate in the experiment the efficacy of the acute destructive pancreatitis and parapancreatitis treatment with application of photodynamic therapy.
Methods. Destructive pancreatitis, parapancreatitis were modeled in 20 laboratory animals (rabbits). Two groups were determined. In the 1st (control one, 10 animals) purulent pancreatitis was modeled; treatment wasn’t applied. In the 2nd group (experimental one, 10 animals) the day after destructive pancreatitis modeling the preparation Photolon was used locally in the foci of destruction, an hour later low-intensity laser radiation was applied. Clinical course was estimated, general and biochemical blood tests indexes were studied. Morphological investigations were performed in case of the death of an animal in the control group and in case of excluding from the experiment in the experimental group.
Results. In the experimental animals, destructive pancreatitis, parapancreatitis developed causing the death of animals after ADPP modeling in the control group. In the experimental group one noted the positive dynamics after photodynamic therapy in general state of animals. In the laboratory data one noted stabilization of general and biochemical blood tests. Macro- and microscopically limitation of the inflammatory reaction took place and not spreading of it.
Conclusions. Application of photodynamic therapy at acute destructive experimental pancreatitis, parapancreatitis leads to the reduction and limitation of inflammation in the pancreas and retroperitoneal fat.

Keywords: acute destructive pancreatitis, parapancreatitis, experiment, photodynamic therapy, Photolon, local administration of photosensitizer
p. 12 – 19 of the original issue
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