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Khirurgii
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Year 2011 Vol. 19 No 2

GENERAL AND SPECIAL SURGERY

KUGAEV M.I., SCHASTNY A.T., SAMSONOVA I.V.

RELATIONSHIP OF THE PATHOMORPHOLOGICAL CHANGES IN THE PANCREATIC HEAD WITH PAIN SYNDROME INTEN INTENSITY

Objectives. To investigate the relationship between the indicators of quality of life, severity of pain and morphological changes in the pancreas (P) in chronic pancreatitis (CP)
Methods. 51 patients were examined. To evaluate the intensity of pain the visual analogue scale (VAS was used); to examine the quality of life (QOL) questionnaire SF-36 was used. Material for microscopic examination was taken during the resection of the pancreas head.
Results. A wide range of fibrotic changes in the pancreas head was revealed. The correlation between the intensity of pain, QOL and an area of fibrosis wasnt found. When comparing groups of patients with pancreatic head size of less than 40 mm and more than 40 mm, the area of fibrosis was not significantly different. When comparing groups of patients with the width of the main pancreatic duct (MPD) of less than 6 mm and more than 6 mm, the area of fibrosis was not significantly different.
Conclusions. QOL and intensity of pain dont correlate with the degree of fibrotic changes occurring in the pancreas head. Pancreatic head size and width of the main pancreatic duct dont depend on the degree of fibrotic changes in the pancreas head.

Keywords: chronic pancreatitis, fibrosis of the pancreas, the quality of life, intensity of pain, the width of the main pancreatic duct, the size of the pancreatic head
p. 31 36 of the original issue
References
  1. , . . / . . , . . // . . i. 2003. 4. . 8-12.
  2. , . . : , / . . // . . 2002. 1. . 39-42.
  3. Amman, R. W. The natural history of pain in alcoholic chronic pancreatitis / R. W. Amman, B. Muellhaupt // Gastroenterology. 1999. Vol. 116. P. 11321140.
  4. Chronic pancreatitis: the perspective of pain generation by neuroimmune interaction / P. Di Sebastiano [et al.] // Gut. 2003. Vol. 52. P. 907-911.
  5. Monkemuller, K. E. Endoscopic therapy of chronic pancreatitis / K. E. Monkemuller, S. Kahl, P. Malfertheiner // Dig. Dis. 2004. Vol. 22. P. 280-291.
  6. , . . / . . , . . , . . . : , 1999. 356 .
  7. Beger, H. Chronic pancreatitis. Current surgical therapy / H. Beger, M. Siech. A Harcourt Heals Sciens Company, 2001. P. 551-557.
  8. , / . . [ .] // . . . . . . 2006. 8. . 3-10.
  9. Di Magno, E. P. Chronic pancreatitis / Eds. E. P. Di Magno, J. D. Gardner // The pancreas. 21-st ed. New York: Raven Press, 1993. P. 655-706.
  10. Duodenum-preserving resection of the head of the pancreas in severe chronic pancreatitis. Early and late results / H. Beger [et al.] // Ann. Surg. 1989. Vol. 209. P. 273-278.
  11. Elsasser, H. P. Time course and cellular source ofpancreatic regeneration following acute pancreatitis / H. P. Elsasser, G. Adler, H. F. Kern // Pancreas. 1986. Vol. 5. P. 421-429.
  12. Van Laethem, J. L. Pancreatitis and cytokines / J. L. Van Laethem, J. Deviere // Acta Gastroenterol. Belg. 1996. Vol. 59. P. 186-187.
  13. Role of extracellular matrix in pancreatic diseases / T. M. Gress [et al.] // Digestion. 1998. Vol. 59. P. 625-637.
  14. Shimizu, K. Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis / K. Shimizu // J. Gastroenterol. 2008. Vol. 43. P. 823-832.
  15. Course and outcome of chronic pancreatitis: Longitudinal study of a mixed medical-surgical series of 245 patients / R. W. Ammann // Gastroenterology. 1984. Vol. 86. P. 820-828.
  16. Clinical course and prognosis of chronic pancreatitis / H. Miyake [et al.] // Pancreas. 1987. Vol.2. P. 378-385.
  17. Lankisch, P. G. Natural Course of Chronic Pancreatitis / P. G. Lankisch // Pancreatology. 2001. Vol. 1. P. 3-14.
  18. Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis / P. Di Sebastiano [et al.] // Gastroenterology. 1997. Vol. 112. P. 1648-1655.
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