Novosti
Khirurgii
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Year 2011 Vol. 19 No 3

GENERAL AND SPECIAL SURGERY

SHVALB P.G., KALININ P.E., PSHENNIKOV A.S., SUCHKOV I.A.

EFFECT OF INTERMITTENT PNEUMOCOMPRESSION ON THE NITRIC OXIDE PRODUCTION AS THE MAIN MARKER OF ENOTHELIAL DYSFUNCTION IN PATIENTS WITH PERIPHERAL OCCLUSSIVE ARTERIAL DISEASE

Objectives. To evaluate the efficacy of intermittent pneumocompression (IPC) in the complex treatment of the peripheral occlusive arterial disease (POAD).
Methods. In the investigation 2 groups of patients were included: the first study group included 64 patients, who underwent the pneumocompression course) and the second one (60 patients) and they included patients with POAD at the stage II - IIB according to the classification of Fontaine in modification of Pokrovsky. We used a special program to register the levels of metabolites of nitric oxide, ankle-brachial pressure index, reactive hyperemia test (RH - test), pain-free walking distance which were monitored before IPC and after 1-month follow-up.
Results. It was found out that the use of IPC in treatment of patients with POAD is pathogenetically based upon the normalization of functional state of endothelium and has some advantages compared to the classical methods of conservative treatment. We observed the elevation of nitric oxide level which is the key mechanism of clinical improvement such as the increase of pain-free walking distance, ankle-brachial pressure index as well as improved RH-test.
Conclusion. A short-course intermittent pneumocompression is one of the methods of endotheliotropic treatment and is an aspect to be considered in combination therapy in patients with peripheral occlusive arterial disease.

Keywords: Intermittent pneumocompression, endothelial dysfunction, nitric oxide
p. 77 81 of the original issue
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