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Year 2013 Vol. 21 No 3


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SBEE HPE Kursk State Medical University,
The Russian Federation

Objectives. To compare tissue reaction of an arterial wall to implantation of synthetic and biological endoprostheses.
Methods. The analysis of the experiment study on 30 rabbits divided into one intact group numbering 6 animals and two trial groups numbering 12 animals in each one has been carried out. In the first group the animals had implantation of the synthetic polytetraftorethylene prosthesis on the aortic wall, whereas a biological vascular prosthesis made from the bovine internal chest arteries was implanted into the rabbits aortic wall in the second group. The areas of the abdominal aorta together with the implanted endoprostheses were subjected to the histological study on the 3, 7, 14, 21, 30 60 days after the operation. The preparations were studied under light microscope after being stained with hematoxylin-eosin and on Van Gieson. Morphometric study to determine the proportion of cellular composition of the connective tissue was performed.
Results. Both synthetic and biological grafts at implantation caused an acute inflammatory reaction within 7 days, which was more expressed under the biological graft on the 3rd day (3,2 folds) and on the 7th day 1,2 folds. 2 weeks after the implantation the inflammatory reaction was stopped and reparative processes of the new granulated tissue formation began to prevail in arterial wall. Faster formation of the connective tissue capsule under the synthetic graft was registered later. On the 30th day a mature connective tissue is formed and the capsular formation processes completes on the 60th day. On the 30th day of experiment the connective tissue capsule under the biological graft was 1,8 folds thinner, on the 60th day 3,3 folds thinner than under the synthetic graft. The connective tissue capsule surrounded the synthetic vascular prosthesis contained more cellular elements whereas the fibrous structures prevail surrounded the biological prosthesis.
Conclusions. The tissue reaction of the arterial wall to the implantation of the biological graft is less expressed than to the implantation of the synthetic graft.

Keywords: tissue reaction, artery, polytetraftorethylene prosthesis, biological prosthesis
p. 9 15 of the original issue
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Address for correspondence:
305041, Rossiiskaia Federatsiia, g. Kursk, ul. K. Marksa, d. 3, GBOU VPO "Kurskii Gosudarstvennyi meditsinskii universitet", kafedra obshchei khirurgii,
Sukovatykh Boris Semenovich
Information about the authors:
Sukovatykh B.S. MD, professor, a head of the general surgery chair of SBEE HPE Kursk State Medical University.
Vedenev Y.I. A head of the pathoanatomical
department of the Regional budget establishment of health care of the city clinical emergency hospital of Kursk.
Rodionov A.O. An intramural post-graduate student of the general surgery chair of SBEE HPE Kursk State Medical University.
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