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Year 2014 Vol. 22 No 4


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SE Republican Scientific Practical Center Cardiology1,
SEE Belarusian Medical Academy of Post-Graduate Education 2, Minsk,
The Republic of Belarus

Objectives. To evaluate the immediate clinical results of aortic valve replacement with allografts.
Methods. Aortic valve replacement with allografts has been performed in 40 patients. Cryopreserved allografts were used in 33 cases (82,5%); fresh sterilized allografts in 5 (12,5%); homovital allografts in 2 (5%).
Indications for allograft use were: infective endocarditis of aortic valve (11 patients, 27,5%), prosthetic valve endocarditis (15 patients, 37,5%), prosthetic dysfunction (3 patients, 7,5%), aortic valve defects of different etiology (11 patients, 27,5%). Dimensions of allografts varied from 21 mm to 27 mm. The prosthetics has been performed as full root replacement in 35 cases (87,5%), the technique of subcoronary allograft implantation in 5 cases (12,5%).
Results. The 30-day postoperative mortality rate was 15,0% (6 patients). At discharge the peak gradient was 17,912,4 mm Hg for the 21-mm prosthesis, 16,08,3 mm Hg for 23-mm prosthesis, 10,83,1 mm Hg for 25-mm prosthesis, 8,73,8 mm Hg for 27-mm prosthesis.
Conclusions. Early postoperatively the allografts in aortic position show low transprosthetic gradient. regardless of the valve size implanted. Allograft implantation is considered to be an alternative to mechanical and biological prostheses in patients with infective and prosthetic endocarditis, as well as in elderly patients with a narrow aortic annulus diameter.

Keywords: aortic valve replacement, cryopreserved aortic allograft, infectious endocarditis
p. 443 448 of the original issue
  1. Carrel A. The preservation of tissues and its applications in surgery. 1912. Clin Orthop Relat Res. 1992 May;(278):2-8.
  2. Schuster SR, Gross RE. Surgery for coarctation of the aorta. A review of 500 cases. J Thorac Cardiovasc Surg. 1962 Jan;43:54-70.
  3. Cervantes J. Reflections on the 50th anniversary of the first abdominal aortic aneurysm resection. World J Surg. 2003 Feb;27(2):246-8.
  4. Lam CR, Aram HH, Menneli ER. An experimental study of aortic valve homografts. 1952. Surg Gynecol Obstet. 94 129-135.
  5. Bokeriia LA, Sukhanov SG, Kashin VA, Maslov IuN, Mosiiash VB. Ispol'zovanie allograftov vlazhnogo khraneniia v khirurgii infektsionnogo endokardita aortal'nogo klapana [The wet-stored allograft application in surgery of infective endocarditis of the aortic valve]. Annaly Khirurgii. 2009;(6):8791.
  6. Silver MD, Tuffnell PG, Bigelow WG. Endocarditis caused by Paecilomyces varioti affecting an aortic valve allograft. J Thorac Cardiovasc Surg. 1971 Feb;61(2):278-81.
  7. Duran CG, Gunning AJ. A method for placing a total homologous aortic valve in the subcoronary position. Lancet. 1962 Sep 8;2(7254):48889.
  8. O'Brien MF, McGiffin DC, Stafford EG.Allograft aortic valve implantation: techniques for all types of aortic valve and root pathology. Ann Thorac Surg. 1989 Oct;48(4):6009.
  9. Hoquel R, Rashid Z, Sarkar SK.Antibiotic sterilization of cadaveric homograft aortic valve for clinical use. Bangladesh Med Res Counc Bull. 2007 Aug;33(2):6972.
  10. Spiridonov SV, Iudina OA, Shket AP, Chesnov IuM, Dryk SI, Odintsov VO, Shchetinko NN, Zuenok NN, Ostrovskii IP. Varianty predimplantatsionnoi podgotovki kriosokhranennykh allograftov [Variants of preimplantation preparation of cryopreserved allografts]. Novosti Khirurgii. 2013;21(2):7681.
  11. Maselli D, Pizio R, Bruno LP, Di Bella I, De Gasperis C.Left ventricular mass reduction after aortic valve replacement: homografts, stentless and stented valves. Ann Thorac Surg. 1999 Apr;67(4):96671.
  12. Bisdas T, Wilhelmi M, Haverich A, Teebken OE. Cryopreserved arterial homografts vs silver-coated Dacron grafts for abdominal aortic infections with intraoperative evidence of microorganisms. J Vasc Surg. 2011 May;53(5):1274-1281.e4.
Address for correspondence:
220036, Respublika Belarus, g. Minsk, ul. R. Lyuksemburg, d. 110, GU RNPTs Kardiologiya, 2-e kardiokhirurgicheskoe otdelenie,
Spiridonau Sergey Viktorovich
Information about the authors:
Spirydonau S.V. PhD, a cardiac surgeon of SE RSPC Cardiology.
Shket A.P. PhD, a cardiac surgeon, a head of the 2nd cardiac surgery unit of SE RSPC Cardiology.
Chesnov Y.M. MD, a cardiac surgeon of SE RSPC Cardiology.
Shchatsinka N.N. A cardiac surgeon of SE RSPC Cardiology.
Adzintsou V.O. A cardiac surgeon of SE RSPC Cardiology.
Shumavetz V.V. PhD, a cardiac surgeon of SE RSPC Cardiology.
Andruschuk V.V. PhD, a cardiac surgeon of SE RSPC Cardiology.
Komarovsky V.V. A cardiac surgeon of SE RSPC Cardiology.
Ostrovsky Y.P. MD, professor, a corresponding member o NAS RB, a head of the laboratory of the heart surgery of SE RSPC Cardiology, a head of the cardiac surgery chair of SEE Belarusian Medical Academy of Post-graduate Education.
Contacts | ©Vitebsk State Medical University, 2007