Novosti
Khirurgii

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Year 2015 Vol. 23 No 1

ANESTHESIOLOGY & REANIMATOLOGY

A.L. LIPNITSKI, A.V. MAROCHKOV

COMPARATIVE EVALUATION OF CISATRACURIUM AND ATRACURIUM ACTION AS COMPONENTS OF ENDOTRACHEAL ANESTHESIA IN LAPAROSCOPIC SURGERIES

ME "Mogilev Regional Hospital",
The Republic of Belarus

Objectives. To carry out the comparative evaluation of cisatracurium and atracurium as a component of a balanced endotracheal anesthesia for the abdominal laparoscopic surgeries.
Methods. 80 patients at the age of 18-70, who had undergone the laparoscopic cholecystectomy, were enrolled in the prospective randomized study. All patients received cisatracurium 0,1 mg / kg (the 1st group) or atracurium 0,3 mg / kg (the 2nd group). Monitoring of neuromuscular transmission is carried out according to Stockholm criteria of the pharmacodynamic studies of myorelaxants action.
Results. Cisatracurium administration (270 (225-330) had faster onset time of neuromuscular block in comparison with the 2nd – 390 (210-540) (p<0,01). In the 1st group intubation conditions were excellent in 28 (66,7%) cases, in the 2nd group – in 13 (34,2%) patients (p<0,05), and poor – in 3 cases (1st group), in 12 cases, (p<0,05) in the 2nd group. Duration of action of atracurium was reliably lower – 31,5 (25-37) min in comparison with cisatracurium – 43 (40-50) min (p<0,05). In atracurium group total number of complications / side effects was higher than in cisatracurium group, in 2nd group – 16 and 5 – in the 1st group (p<0,05). Serious complications related to regional anesthesia have not been observed.
Conclusion. Low doses of cisatracurium (0,1 mg/kg) cause faster onset and create better conditions for tracheal intubation, compared with that of atracurium. Cisatracurium (0,1 mg/kg) proved tî have a longer duration of action than atracurium (0,3 mg/kg).

Keywords: myorelaxants, cisatracurium, atracurium, neuromuscular block, general anesthesia, randomized controlled trial
p. 91-96 of the original issue
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Address for correspondence:
212002, Respublika Belarus,
g. Mogilev, ul. B. Biruli d. 12,
ME "Mogilev Regional Hospital",
otdelenie anesteziologii i reanimatsii,
tel. office: +375 222 278 733,
e-mail: lipnitski.al@gmail.com,
Lipnitski Artur Leonidovich
Information about the authors:
Lipnitski A.L. A head of the transplant-coordination department of ME "Mogilev Regional Hospital".
Marochkov A.V. MD, professor, a head of the anesthesia and intensive care department of ME "Mogilev Regional Hospital".
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