Novosti
Khirurgii
This journal is
indexed in Scopus



Year 2015 Vol. 23 No 4

GENERAL & SPECIAL SURGERY

DOI: http://dx.doi.org/10.18484/2305-0047.2015.4.385   |  

V.M. MAYOROV 1, Z.A. DUNDAROV 1, Y.N. AVIZHETS2

SOME MORPHOLOGICAL REGULARITIES OF DAMAGE AND SPREADING OF THE DESTRUCTIVE PROCESS IN THE RETROPERITONEAL AREA IN SEVERE ACUTE NECROTIZING PANCREATITIS ACCORDING TO AUTOPSY DATA

EE "Gomel State Medical University" 1,
E "Gomel Regional Clinical Pathoanatomical Bureau" 2,
The Republic of Belarus

Objectives. The study of regularities of spreading of the pathological process in the retroperitoneal area in severe destructive pancreatitis.
Methods. The ongoing retrospective analysis according to the report of 180 autopsy cases revealing the acute destructive pancreatitis (the data of Gomel regional clinical pathoanatomical bureau (1990-2014) was carried out during the research.
Results. The performed analysis of morphological changes of internal organs showed that the cause of early lethal outcomes is a massive enzymatic uncorrected intoxication. Fulminant necrotizing pancreatitis was registered in 70 cases, composing 38,9% of all observations. The first five days these patients have been subjected to intensive therapy due to incurable pancreatogenic shock in the intensive care unit. Particular attention was paid to the peculiarities of the anatomical relationship between destructive changes of the pancreas and affected peripancreatic cellular tissue. The obligate lesion of the peripancreatic cellular tissue in the presence of necrotic foci in the pancreatic parenchyma was established.
The actual total number of cases of total pancreatic necrosis revealed by autopsy was appeared fewer than initially assumed according to clinical and intraoperative examinations.
In case of massive pancreatic parenchymal necrosis reaching 30-60% of the pancreatic parenchyma, the formation of large peripancreatic sequesters, encapsulated in anatomically multiple closed cavities and maintaining high level of tissue intoxication has been constantly observed. Analysis of surgical treatment results detected one of the main reasons of deaths from pancreatitis surgery was suppurative necrotic parapancreatitis.
Conclusion. Pancreatogenic shock with its complications was detected as a main cause of death. Morphological manifestations of pancreatogenic shock were: enzymatic serosanguineous peritonitis and generalized parapancreatitis, massive atelectasis and pulmonary edema with hemorrhages, edema, and swelling of the brain as well as the marked dystrophic changes of parenchymal organs.

Keywords: acute necrotizing pancreatitis, parapancreatitis, total and large focal pancreatic necrosis, pancreatogenic shock, tissue intoxication, multiple organ failure, autopsy study
p. 385-390 of the original issue
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Address for correspondence:
246000, Republic of Belarus,
g. Gomel, ul. Bratev Lizyukovyih, d. 5,
UO "Gomel'skii gosudarstvennyi
meditsinskii universitet"
kafedra khirurgicheskih bolezney №2
s kursami anesteziologii i detskoy khirurgii,
tel.mob. 375 29 328 54 43,
e-mail: vadim.mayorov.1973@mail.ru,
tel.mob. 375 29 328 54 43,
Mayorov Vadim Mihaylovich
Information about the authors:
Dundarov Z.A. MD, professor, a head of the surgical diseases chair №2 with a course of anesthesiology and pediatric surgery of EE "Gomel State Medical University".
Mayorov V.M. PhD, an associate professor of the surgical diseases chair №2 with a course of anesthesiology and pediatric surgery of EE "Gomel State Medical University".
Avizhets Y.N. A head of the pathoanatomical department №1 of E "Gomel Regional Clinical Pathoanatomical Bureau".
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