This journal is
indexed in Scopus
Year 2016 Vol. 24 No 4
A.O. BAIYRKHANOVA1, T.K. BOTABEKOVA2, Y.M. SEMENOVA1
THE STUDY OF ANTI-PROLIFERATIVE EFFECT OF INTRAVITREAL IMPLANT IN SURGICAL TREATMENT OF PROLIFERATIVE VITREORETINOPATHY
Semey State Medical University1, Semey
JSC "Scientific Research Institute of Eye Diseases of the Badge of Honor Order"2 of Kazakhstan, Almaty
The Republic of Kazakhstan
Objectives. To study the anti-proliferative effect of chitosan film (ChF) in surgical treatment of experimental proliferative vitreoretinopathy (PVR) by the ultrasound method (US).
Methods. This study has been conducted on 10 adult rabbits (20 eyes) of “chinchilla” breed weighing 2,5 – 4,0 kg. To develop an experimental PVR the autohemotherapy (0,4 ml) is used. The eyes of animals were divided into 4 groups: the 1st and 2nd – the main groups – 10 right eyes (5 eyes – the implantation of ChF saturated with 5-fluorouracil (5-FU) and 5 eyes – ChF without 5-FU), the 1st and 2nd control groups – 10 left eyes (without implanting the film). On the 10th and 31st days after operation the anti-proliferative effect has been compared.
Results. On the 10th day the partial hemophthalmos in 4 eyes of the 1st and 2nd main groups and in all eyes of control groups has been noted. There was a vitreoretinal cord in the posterior part in 4 eyes of the 1st and 2nd control groups. On the 31st day in 2 eyes of the 1st main group turbidity of a vitreous body was observed. In 1 eye of the Ist main group and 3 eyes of the 2nd main group the partial hemophthalmos was noted. A vitreoretinal cord was visualized in 3 eyes of the 2nd main group. In all eyes of the control groups a hemophthalmos in the forming stage was observed, and the posterior covers were thickened. There was a vitreoretinal cord in 4 eyes of the 1st control and in 5 eyes of the 2nd control groups, the whole vitreous body was filled with accurate contours shadows; the exudate – in the posterior part.
Conclusion. Using the chitosan film with 5-fluorouracil enhances the anti-proliferative effect to a great extent. The chitosan film without 5-fluorouracil also blocks the proliferation process, but to a lesser extent. After the morphological studies the given implant can be clinically applied during vitreous surgery to prevent recurrence in the incisional period.
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071400, Republic of Kazakhstan, Semey, Abay str.,103, office 141,
State Medical University.
Tel: 8701720 30 42
Baiyrkhanova A.O. Applicant for Doctor’s degree, Semey State Medical University.
Botabekova T.K. Corresponding member, NAS of the Republic of Kazakhstan, MD, Professor, JSC "Scientific Research Institute of Eye Diseases of the Badge of Honor Order"2 of Kazakhstan, Chairman of the Board, Almaty.
Semenova Y.M. PhD, Head teacher, chair of ophthalmology, Ass. Professor, chair of general surgery, Semey State Medical University.