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Khirurgii

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Year 2016 Vol. 24 No 5

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

S.V. IVANOV, 1 V.A. LAZARENKO1, I.S. IVANOV1, A.V. IVANOV1, A.V. TSUKANOV1, Y.P. ROZBERG1 , L.P. POPOVA2, D.V. TARABRIN1, Y.G. OBYEDKOV1

MORPHOLOGICAL FEATURES OF PARAPROSTHESIS CAPSULE DURING IMPLANTATION OF POLYPROPYLENE AND COMPOSITE ENDOPROSTHESIS AGAINST OROTIC ACID USE IN THE EXPERIMENT

SBEE HPE "Kursk State Medical University" Russian Ministry of Health,
BME "Kursk Regional Clinical Hospital",
Kursk.
The Russian Federation

Objectives. To compare dynamics of connective tissue capsule formation around the polypropylene endoprosthesis and self-expandable prosthesis on the background of the drug stimulating collagen synthesis in experiment.
Methods. The experimental study was performed on mature syngeneic albino mice, (n=185, average weight 45-50 g.). All the animals were divided into 4 series, depending on the application of the endoprosthesis and orotic acid. The number of fibroblast cells, lymphocytes, macrophages and neutrophils was counted in the studied histological preparations of abdominal wall with a fragment of the endoprosthesis, stained with hematoxylin and eosin. The regenerative processes and the capsule paraprotesis formation were evaluated on the basis of the ratio of the cells.
Results. In addition of orotic acid to the animal feed ration the relative amount of fibroblasts was higher in 1,43 and 1,06 fold after implantation of polypropylene and the composite endoprosthesis compared with series without drug application. Dynamics of relative increase of mechanocytes amount in a capsule in implantation of the composite endoprosthesis within 30, 60 and 90 days, was greater than the values in a studied similar series with a polypropylene graft in 1,03, 1,14 and 1,10 fold, respectively.
The obtained findings testified about better biocompatibility of the composite endopropthesis consisting of a polypropylene and polylactic acid, manifested by early proliferation.
Conclusion. The application of a new synthetic composite endoprosthesis consisting of polypropylene and polylactic acid in combination with orotic acid is considered to reduce the intensity of aseptic inflammation in the site of implantation and to optimize collagenogenesis of paraprotesis capsule.

Keywords: orotic acid, polypropylene, polylactic acid, fibroblasts, biocompatibility, ventral hernia, collagen
p. 436-443 of the original issue
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Address for correspondence:
305041, Russian Federation, Kursk,
Karl Marx st., 3, Kursk State Medical University,
department N1of surgical diseases.
Tel: +7 (4742) 35-36-90
E-mail: ivanov.is@mail.ru
Ivanov Ilya Sergeevich
Information about the authors:
Ivanov S.V. MD, Professor, Head of department N1 of surgical diseases, SBEE HPE "Kursk State Medical University".
Lazarenko V.A. MD, Professor, Rector, SBEE HPE "Kursk State Medical University".
Ivanov I.S. MD, Professor of department N1 of surgical diseases, SBEE HPE "Kursk State Medical University".
Ivanov A.V. MD, Professor, Head of department of histology, cytology and embryology, SBEE HPE "Kursk State Medical University".
Tsukanov A.V. PhD, Ass. Professor of department N1of surgical diseases, SBEE HPE "Kursk State Medical University".
Rozberg E.P. MD, Ass. Professor of department N1 of surgical diseases, SBEE HPE "Kursk State Medical University".
Popova L.P. Physician-cytologist, BME "Kursk Regional Clinical Hospital".
Tarabarin D.V. Assistant of department N1 of surgical diseases, SBEE HPE "Kursk State Medical University".
Obyedkov E.G. Assistant of department N1 of surgical diseases.SBEE HPE "Kursk State Medical University".
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