Novosti
Khirurgii
This journal is
indexed in Scopus





Year 2017 Vol. 25 No 2

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

DOI: https://dx.doi.org/10.18484/2305-0047.2017.2.115   |  

Y.M. IRYANOV, D.Y. BORZUNOV, O.V. DYURYAGINA

COMPENSATION OF CAVITARY BONE DEFECTS UNDER IMPLANTATION OF TITANIUM NICKELIDE MESH CONSTRUCTIONS

FSBE Russian Scientific Center Restorative Traumatology and Orthopedics, named after Academician G.A. Ilizarov,
Kurgan,
The Russian Federation

Objectives. To study the morphological features of reparative bone formation in metaphysis cavitary defect filling by implanting mesh constructs of titanium nickelide.
Methods. In adult male rats of Wistar lines in the experimental (n=25) and control (n=25) groups, the metaphysis cavity defects of the femur were modeled. The frame made of titanium-nickelide mesh was implanted into the bone defect in the animals of the experimental group; in the control group no additional manipulations were performed. The total experiment term made up 90 days. The methods of radiography, histology, scanning electron microscopy and X-ray electron probe microanalysis were used; the bone image in the characteristic X-ray of calcium atoms was obtained.
Results. It was found out that on the periosteal surface of the implant, a layer of dense connective tissue was formed to serve as a biological protective barrier preventing the paraosseal connective tissue germination. The microporous surface of the implant provides cell adhesion and tissue integration. Fine-meshed structure of the implant and its nanostructuring surface provide capillary properties, resulting in the adsorption of endogenous bone morphogenetic proteins and growth factors. The functional activity of the latter provides osteoconductivity, osteoinductivity of the implant. Reparative bone formation using the implant is carried out by the direct intramembranous type. Compensation of defect is performed by osseous tissue, the bulk density of which is more than one and a half times higher the control values. Chemical composition of the regenerate, which formed after implantations into the tibial bone defect, approaches to the indices of the trabecular bone of the intact metaphysis. A composite biomaterial is formed in the defect a dense fibrous connective tissue reinforced by the threads of titanium nickelide, a trabecular bone and compact bone.
Conclusion. The mesh constructions of titanium nickelide implant has biocompatibility and marked osteoplastic properties and relieves the inflammatory process. It can be successfully used in orthopedic surgery for the treatment of cavitary defects of bones, especially in patients with impaired reparative potential.

Keywords: bone defect, reparative osteogenesis, implant, mesh constructions, titanium nickelide, biocompatibility, inflammatory process
p. 115-123 of the original issue
References
  1. Liu J, Kerns DG. Mechanisms of guided bone regeneration: a review. Open Dent J. 2014 May 16;8:56-65. doi: 10.2174/1874210601408010056. eCollection 2014.
  2. Kim JY, Yang BE, Ahn JH, Park SO, Shim HW. Comparable efficacy of silk fibroin with the collagen membranes for guided bone regeneration in rat calvarial defects. J Adv Prosthodont. 2014 Dec; 6(6): 539546. Published online 2014 Dec 17. doi: 10.4047/jap.2014.6.6.539.
  3. Jung RE, Fenner N, Hämmerle CH, Zitzmann NU. Long-term outcome of implants placed with guided bone regeneration (GBR) using resorbable and non-resorbable membranes after 12-14 years. Clin Oral Implants Res. 2013 Oct;24(10):1065-73. doi: 10.1111/j.1600-0501.2012.02522.x.
  4. Hämmerle CH, Jung RE. Bone augmentation by means of barrier membranes. Periodontol. 2000. 2003;33:36-53. doi: 10.1046/j.0906-6713.2003.03304.x.
  5. Karring T, Nyman S, Gottlow J, Laurell L. Development of the biological concept of guided tissue regenerationanimal and human studies. Periodontol. 2000. 1993 Feb;1:26-35. doi: 10.1111/j.1600-0757.1993.tb00204.x.
  6. Schmidmaier G, Baehr K, Mohr S, Kretschmar M, Beck S, Wildemann B. Biodegradable polylactide membranes for bone defect coverage: biocompatibility testing, radiological and histological evaluation in a sheep model. Clin Oral Implants Res. 2006;17:439-444. doi: 10.1111/j.1600-0501.2005.01242.x.
  7. Van Leeuwen AC, Huddleston Slater JJ, Gielkens PF, de Jong JR, Grijpma DW, Bos RR. Guided bone regeneration in rat mandibular defects using resorbable poly(trimethylene carbonate) barrier membranes. Acta Biomater. 2012 Apr;8(4):1422-9. doi: 10.1016/j.actbio.2011.12.004.
  8. Iriyanov YM, Chernov VF, Radchenko SA, Chernov AV. Plastic efficiency of different implants used for repair of soft and bone tissue defects. Bull Exp Biol Med. 2013 Aug;155(4):518-21. doi: 10.1007/s10517-013-2191-4.
  9. Iryianov IM, Ir'ianova TIu. Implantat dlia zameshcheniia defekta kosti [An implant to replace the bone defect]. Patent RF 111759, MPK A61F2/28. 27.12.2011.
  10. Mironov SP, Kokorina EP, Andreeva TM, Ogryzko EV. Sostoianie travmatologo-ortopedicheskoi pomoshchi naseleniiu Rossiiskoi Federatsii [State of trauma and orthopedic assistance to the population of the Russian Federation]. Vestn Travmatologii i Ortopedii im NN Priorova. 2007;(3):3-10.
  11. Korzh NA, Kladchenko LA, Malyshkina SV. Implantatsionnye materialy i osteogenez. Rol' optimizatsii i stimuliatsii v rekonstruktsii kosti [Implantation materials and osteogenesis. The role of optimization and stimulation of bone reconstruction]. Ortopediia Travmatologiia i Protezirovanie. 2008;(4 ):5-14.
  12. Uebersax L, Hagenmüller H, Hofmann S, Gruenblatt E, Müller R, Vunjak-Novakovic G, et al. Effect of scaffold design on bone morphology in vitro. Tissue Eng. 2006 Dec;12(12):3417-29. doi: 10.1089/ten.2006.12.3417.
  13. Osyczka AM, Diefenderfer DL, Bhargave G, Leboy PS. Different effects of BMP-2 on marrow stromal cells from human and rat bone. Cells Tissues Organs. 2004;176(1-3):109-19. doi: 10.1159/000075032.
Address for correspondence:
640014, Russian Federation,
Kurgan, M. Ulyanova st., 6, FGBI "Russian Scientific Center "Restorative Traumatology and Orthopaedics named after Acad. GA Ilizarov"
Morphology Lab.
Tel.: +7 (3522) 43-08-83
E-mail: irianov@mail.ru
Yuri M. Iryanov
Information about the authors:
Iryanov Y.M. MD, Professor, Chief Researcher of morphology laboratory, FSBE "Russian Scientific Center "Restorative Traumatology and Orthopedics named after G.A.Ilizarov".
Borzunov D.Y. MD, Deputy Director (Science), FSBE "Russian Scientific Center "Restorative Traumatology and Orthopedics named after G.A.Ilizarov".
Dyuryagina O.V. PhD, Senior Researcher of laboratory of purulent osteology and replacement of limb defects, FSBE "Russian Scientific Center "Restorative Traumatology and Orthopedics named after G.A.Ilizarov".
Contacts | ©Vitebsk State Medical University, 2007