Novosti
Khirurgii
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indexed in Scopus



Year 2017 Vol. 25 No 2

REVIEWS

DOI: https://dx.doi.org/10.18484/2305-0047.2017.2.183   |  

A.T. SHCHASTNY, S.A. SUSHKOU, O.D. MYADELETS, E.I. LEBEDEVA

CHALLENGES AND PROSPECTS OF CELLULAR THERAPY IN TREATMENT OF LIVER DISEASES

EE "Vitebsk State Medical University",
Vitebsk
The Republic of Belarus

It is reported on the results of an international experience, reflecting the achievements in the field of studying of the possibilities of stem cell use in the treatment of pathological processes in the liver, as well as the challenges and prospects of development of this field in medicine. Clinical application of the stem cells for the treatment of liver disease is on the initial stage. Many problems requiring careful investigation are still occurred. One of the main objectives is a search of the optimal source of cells. The priority is given to the optimization of cryo-storage techniques. An actual problem remains the poor survival rate of the cells and elimination by the immune system within a few months after transplantation. There is no consensus on the number of transplanted cells, the multiplicity of ways of their administration, adjuvant therapy with cytokines and growth factors for receiving optimal results. The mechanism of differentiation in hepatocyte direction remains insufficiently studied and controversial. There is a security problem, in particular, related to the possible development of fibrosis involved the transplanted cells, which can aggrevate the course of disease. Despite the absence of direct evidence, there is wariness about the risks of oncogenic transformation of mesenchymal stem cells, as all stem cells have the capacity to self-renew by dividing similar to that of the tumor cells. No optimal method of visualization of transplanted cells exists yet. These problems requires the further laborious research in vitro and in vivo. Overview of the properties of these different types of stem cells can serve as a starting point for researchers working in the conditions of rapid development of stem cell engineering and cell therapy.

Keywords: liver regeneration, differentiation, transplantation, stem cells of the liver and extrahepatic origin cells, stem cell engineering, cell therapy
p. 183-193 of the original issue
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Address for correspondence:
210023, Republic of Belarus,
Vitebsk, Frunze pr., 27,
EE "Vitebsk State Medical University",
Department of histology, cytology and embryology.
Tel.: 375 33 675 76 99
Tel.: 8 0212 60-29-14
E-mail: lebedeva.ya-elenale2013@yandex.ru
Elena I. Lebedeva
Information about the authors:
Shchastny A.T. MD, Professor, Rector, EE "Vitebsk State Medical University".
Sushkou S.A. PhD, Ass. Professor, Vice-rector (Science), EE "Vitebsk State Medical University".
Myadelets O.D. MD, Professor, Head of department of histology, cytology and embryology, EE "Vitebsk State Medical University".
Lebedeva E.I. PhD, Assistant of the department of histology, cytology and embryology, EE "Vitebsk State Medical University".
Contacts | ©Vitebsk State Medical University, 2007