Novosti
Khirurgii
This journal is
indexed in Scopus





Year 2017 Vol. 25 No 2

GENERAL & SPECIAL SURGERY

DOI: https://dx.doi.org/10.18484/2305-0047.2017.2.148   |  

O.S. OLIFIROVA, A.A. KOZKA

VALUE OF ANTIOXIDANTS AND HYPERBARIC OXYGENATION IN TREATMENT OF BURN WOUNDS

FSBEE HE "Amur State Medical Academy" of Ministry of Health of the Russian Federation,
Blagoveshchensk,
The Russian Federation

Objectives. To assess the value of antioxidants and hyperbaric oxygenation in the complex treatment of burn wounds.
Methods. The treatment analysis of 54 patients with I-II-III degree burns (ICD-10) of different localization has been carried out. In the complex treatment of the main group (n=28), the oral administration of antioxidants (the mixture of dihydroquercetin and arabinogalactan, 1:3) 1 capsule twice a day for 21 days was indicated as well as local application of the powder of dihydroquercetin. At the same time in case of I-II degree burns 8-10 sessions of hyperbaric oxygenation of 1,5 to 1,8 atmospheres in the chamber "OKA-M", 40 minutes daily were carried out. In case of III degree burns hyperbaric oxygen was carried out up to delayed autodermoplasty with a free split skin graft and starting from the first postoperative day with in 7 days. The clinical comparison group was comprised of patients (n=26) who received the traditional treatment.
Results. In patients of the main group who received antioxidant therapy and hyperbaric oxygenation the course of wound healing is characterized by even process, manifested in reduction of pain syndrome and the temperature reaction, in the early appearance of granulation, marginal and complete epithelialization of wounds of I-II degree burns was noted, as well as the reduction of preoperative preparation terms of III degree burns. Due to the stimulation of reparative processes, complete engraftment of the split free autodermotransplant was achieved in 100% of cases in the main group and only in 72,4% in the clinical group. Hyperproduction of pro-inflammatory interleukins (IL-1β, IL-6, IL-8, TNF-α) was observed in all patients, however, to the 21st day of treatment, its significant reduction was registered in the main group. Antioxidants and hyperbaric oxygen application permitted to reduce the intensity of lipid peroxidation and to increase the activity of antioxidant protection system.
Conclusion. The conducted study showed the efficacy of application of antioxidants and hyperbaric oxygen therapy in complex treatment of patients with burn wounds.

Keywords: burn wounds, dihydroquercetin, arabinogalactan, hyperbaric oxygenation, engraftment, lipid peroxidation, pro-inflammatory cytokines
p. 148-154 of the original issue
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Address for correspondence:
675000, Russian Federation,
Blagoveshchensk, Gorky str., 95,
FGBOU Amur State Medical Academy
Faculty of Postgraduate Education,
Department of surgical diseases.
Tel.: 7 914 554-46-52
e-mail: olif.oc@mail.ru
Olga S.Olifirova
Information about the authors:
Olifirova O.S. MD, Ass. Professor, Head, department of surgical diseases, FSBEE HE "Amur State Medical Academy" of Ministry of Health, the Russian Federation, Blagoveshchensk.
Kozka A.A. Post-graduate student of department of surgical diseases, FSBEE HE "Amur State Medical Academy" of Ministry of Health, the Russian Federation, Blagoveshchensk.
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