Novosti
Khirurgii
This journal is
indexed in Scopus



Year 2018 Vol. 26 No 1

GENERAL & SPECIAL SURGERY

DOI: https://dx.doi.org/10.18484/2305-0047.2018.1.51   |  

R.E. KALININ, I.A. SUCHKOV, A.S. PSHENNIKOV, A.A. KAMAEV, S.A. ISAKOV, A.N. RYABKOV

APPLICATION OF MAGNESIUM DRUGS AND THEIR INFLUENCE ON THE INDICATORS OF CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH VARICOSE VEINS

Ryazan State Medical University
named after Academician I.P. Pavlov, Ryazan,
The Russian Federation

Objective. To study the effect of magnesium drugs on the concentration of matrix metalloproteinases and magnesium ions in patients with varicose veins of the lower extremities.
Methods. The study included 124 patients with varicose veins of the lower extremities, C2-C6, which were divided into 4 groups. In the 1st group, surgical treatment followed with the administering the standard conservative treatment (32 patient); in the 2nd group after the operation in addition to conservative treatment, magnesium drugs (32 patient) were prescribed; in the 3rd group, conservative treatment without surgery (30 patient) was performed; in the 4th group patients received standard conservative treatment and magnesium drugs (30 patient). The 5th control group consisted of 20 healthy volunteers who did not suffer from varicose veins disease. Patients of groups 2 and 4 were given magnesium orotate 500 mg 2 tablets 3 times a day for 3 months. The content of serum matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) was determined by quantitative solid-phase enzyme immunoassay. The magnesium ion concentration was determined by colorimetric method.
Results. In patients with varicose veins of lower extremities a significantly lower level of magnesium was registered compared to healthy volunteers not suffering from varicose veins: 35.5% of those with varicose veins had a magnesium deficiency, while only 15% had a decrease in this indicator among healthy volunteers. Against the background of additional therapy with magnesium drugs, there was a decrease in the number of patients with magnesium deficiency in groups with varicose veins of lower extremities, a decrease in MMP-9 concentration and an increase in TIMP-1 activity was also established.
Conclusions. This study has confirmed the efficacy of magnesium drugs which have a pronounced effect on collagen degradation processes and extracellular matrix, reduce the activity of MMP-9, increase the concentration of TIMP-1, thereby affecting the MMP/TIMP balance in patients with varicose veins of lower extremities.

Keywords: primary varicose veins, pharmacotherapy, magnesium, matrix metalloproteinase, connective tissue dysplasia
p. 51-89 of the original issue
References
  1. Pokrovskii AV, Gradusov EG, Bredikhin RA. Diagnostika i lechenie varikoznoi bolezni. Moscow, RF: RMAPO; 2013. 125 p. (in Russ.)
  2. Staffa R. Chronic venous insufficiencyepidemiology. Bratisl Lek Listy. 2002;103(4-5):166-68.
  3. Nebylitsyn IuS, Kondrateva VI. Experience of managing patients with primary varicosity. Nauka molodykh Eruditio Juvenium. 2016;(3):52-66. (in Russ.)
  4. Kirienko AI, Bogachev VIu, Gavrilov SG, Zolotukhin IA, Golovanova OV, Zhuravleva OV, Briushkov AIu. Chronic diseases of lower extremity veins in industrial workers of Moscow (Results of the epidemiological survey). Angiologiia i Sosud Khirurgiia. 2004;10(1):77-85. (in Russ.)
  5. Seliverstov EI, Avakiants IP, Nikishkov AS, Zolotukhin IA. Epidemiology of chronic venous disease. Flebologiia. 2016;10(1):35-43. doi: 10.17116/flebo201610135-42. (in Russ.)
  6. Fomina NV, Fomina MA. Assessment of communication activity of lysosomal cystein proteases in plasma and indicators of endothelial dysfunction in patients with diseases of lower limbs veins. Nauka molodykh Eruditio Juvenium. 2014;(1):60-67. (in Russ.)
  7. Amălinei C, Căruntu ID, Giuşcă SE, Bălan RA. Matrix metalloproteinases involvement in pathologic conditions. Rom J Morphol Embryol. 2010;51(2):215-28.
  8. Gromova OA. Magnii i piridoksin: osnovy znanii. Moscow, RF: ProtoTip; 2006. 234 p. (in Russ.)
  9. Gromova OA, Kalacheva AG, Torshin IIu, Rudakov KV, Grustlivaia UE, Iudina NV, Egorova EIu, Limanova OA, Fedotova LE, Gracheva ON, Nikiforova NV, Satarina TE, Gogoleva IV, Grishina TR, Kuramshina DB, Novikova LB, Lisitsyna EIu, Kerimkulova NV, Vladimirova IS, Chekmareva MN, Lialiakina EV, Shalaeva LA, Taleporovskaia SIu, Siling TB, Prozorova NV, Semenov VA, Semenova OV, Nazarova NA, Galustian AN, Sardarian IS. Nedostatochnost magniia dostovernyi faktor riska komorbidnykh sostoianii: rezultaty krupnomasshtabnogo skrininga magnievogo statusa v regionakh Rossii. Farmateka. 2013;(6):115-29. (in Russ.)
  10. Pagès N, Gogly B, Godeau G, Igondjo-Tchen S, Maurois P, Durlach J, Bac P. Structural alterations of the vascular wall in magnesium-deficient mice. A possible role of gelatinases A (MMP-2) and B (MMP-9). Magnes Res. 2003 Mar;16(1):43-48.
Address for correspondence:
390026, The Russian Federation,
Ryazan, Vyisokovoltnaya str., 9,
Ryazan State Medical University
named after Academician I.P. Pavlov,
Department of Cardiovascular,
X-Ray Endovascular,
Operative Surgery and Topographic Anatomy,
Tel. 7 951 101-21-23,
e-mail: kamaev.rgmu@gmail.com,
Kamaev Aleksey Andreevich
Information about the authors:
Kalinin Roman E., MD, Professor, Head of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy of Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-0817-9573
Suchkov Igor A., MD, Associate Professor, Professor of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy of Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-1292-5452
Pshennikov Alexander S., PhD, Associate Professor of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy of Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-1687-332X
Kamaev Aleksey ., Post-Graduate Student of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy of Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-3979-1271
Isakov Sergey ., MD, Professor of the Dermatovenereology Department of Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-0694-1309
Ryabkov Alexander N., MD, Associate Professor of the Department of Pharmacology with the Course of Pharmacy of the Faculty of Additional Professional Education of Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0003-4705-747X
Contacts | ©Vitebsk State Medical University, 2007