Novosti
Khirurgii
This journal is
indexed in Scopus



Year 2018 Vol. 26 No 3

GENERAL & SPECIAL SURGERY

DOI: https://dx.doi.org/10.18484/2305-0047.2018.3.293   |  

I.S. IVANOV 1, V.I. TEMIRBULATOV 1, 2, M.E. KLETKIN 2, O.A. OKUNEV 1, I.A. IVANOVA 1

CORRELATION OF COLLAGEN TYPE I AND III IN THE SKIN AND LUNGS IN PATIENTS WITH BULLOUS EMPHYSEMA COMPLICATED BY SPONTANEOUS PNEUMOTHORAX

Kursk State Medical University 1,
Kursk regional clinical hospital 2, Kursk
The Russian Federation

Objective. To study the correlation of type I and III collagens of the connective tissue in the skin and lungs in patients with the bullous emphysema complicated by spontaneous pneumothorax and without it.
Methods. A comparative analysis of the content of type I and III collagens in the skin and lung in 32 patients with the lung bullous emphysema complicated by spontaneous pneumothorax and control group (autopsy material from 30 people without obvious pathology of the lungs) was carried out. The study of type I and III collagens in the skin and lungs was carried out using polarization microscopy, which allows revealing the correlation of collagen types in patients of the studied groups.
Results. It has been found out that patients with the bullous emphysema have a significantly lower ratio of type I and III collagens in both the skin and lung preparations in comparison with the control group. A high direct correlation has been registered between the correlation of collagen types of the skin and lungs connective tissue in both groups.
Conclusions. The patients with the bullous emphysema have a significantly lower ratio of type I and III collagens in the skin and lungs. The presence of a high direct correlation between the content of different types of collagen in the skin and lungs, both in the main and control groups, allows identifying the systemic pathology of the connective tissue only by its changes in the skin of patients. Determination of the relative ratio of type I and III collagens in preparations of the skin and lung with the use of polarization microscopy has high informative value in the verification of the bullous emphysema as one of the manifestations of connective tissue dysplasia.

Keywords: bullous emphysema, spontaneous pneumothorax, collagen type I, collagen type III, polarized microscopy
p. 293-300 of the original issue
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Address for correspondence:
305007, The Russian Federation,
Kursk, Sumskaya Str., 45 ,
Kursk Regional Clinical Hospital,
Thoracic Surgery Unit,
Tel.: +7 903 875-30-58,
e-mail: kletkin-max@mail.ru,
Maxim E. Kletkin
Information about the authors:
Ivanov Ilia S., MD, Professor of the Department of Surgical Diseases 1, Kursk State Medical University, Kursk, Russian Federation.
https://orcid.org/0000-0003-4408-961X
Temirbulatov Vladimir I., MD, Professor of the Department of Surgical Diseases FPED, Kursk State Medical University, Head of the Thoracic Surgery Unit, Kursk Regional Clinical Hospital, Kursk, Russian Federation.
https://orcid.org/0000-0003-3757-924X
Kletkin Maxim E., Physician of the Thoracic Surgery Unit, Kursk Regional Clinical Hospital, Kursk, Russian Federation.
https://orcid.org/0000-0003-3886-5272
Okunev Oleg A., PhD, Assistant of the Department of Surgical Diseases 1, Kursk State Medical University, Kursk, Russian Federation.
https://orcid.org/0000-0002-2298-1546
Ivanova Inna A., PhD, Associate Professor of the Department of Clinical Immunology and Allergology, Kursk State Medical University, Kursk, Russian Federation. https://orcid.org/0000-0001-5175-6586
Contacts | ©Vitebsk State Medical University, 2007