Novosti
Khirurgii
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indexed in Scopus



Year 2019 Vol. 27 No 1

REVIEWS

DOI: https://dx.doi.org/10.18484/2305-0047.2019.1.91   |  

R.E. KALININ, I.A. SUCHKOV, A.S. PSHENNIKOV, S.A. VINOGRADOV

MARKERS OF ARTERIOVENOUS DIFFERENTIATION OF ENDOTHELIAL CELLS AND THEIR INFLUENCE ON ADAPTATION OF AUTOVENOUS CONDUITS IN MAIN ARTERIES RECONSTRUCTIVE SURGERY

Ryazan State Medical University, Ryazan,
The Russian Federation

Revascularization of the occluded arterial segments is currently the main treatment method in patients with critical limb ischemia. Discussions regarding the choice of the best conduit for the reconstructive procedures on the femoro-popliteal-tibial segments have been continuing over the last five decades. Autovenous conduits using the great saphenous vein remain the golden standard in vascular reconstructive surgery. However, up to 50% of autovenous transplants lose patency within 5 years. Reaction of venous conduit to arterial circulation and its morphofunctional changes are not fully described in present-day medical literature. Markers of embryonic arteriovenous differentiation of endothelial cells determining the faith of both arteries and veins have gained popularity within past years. Ephrin-B2 is specifically expressed in arterial endothelium while Eph-B4 is expressed in venous endothelial cells. Arterialization of the autovenous conduit is characterized by the loss of the venous marker Eph-B4 without obtaining the arterial marker Ephrin-B2, which is accompanied by the negative morphological remodeling of the venous wall, i.e. its thickening. Eph-B4 in venous endothelium interacts with a number of molecules including eNOS, caveolin and others, thus regulating the process of adaptation. Further studies of the adaptation of venous conduits to arterial circulation may help improve our understanding of this process and results of the autovenous reconstructive procedures.

Keywords: endothelium, autovenous bypass, arterialization of the venous conduit, adaptation of the autovenous conduit, atherosclerosis, endothelial dysfunction, eph-B4, ephrin-B2
p. 91-100 of the original issue
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Address for correspondence:
390026, The Russian Federation,
Ryazan, Vysokovoltnaya Str.,9,
Ryazan State Medical University,
Department of Cardiovascular, Endovascular,
Operative Surgery and Topographic Anatomy.
Tel. +7 910 900-95-23,
e-mail: pshennikov1610@rambler.ru,
Alexander S. Pshennikov
Information about the authors:
Kalinin Roman E., MD, Professor, Rector, Head of the Department of Cardiovascular, Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russian Federation.
http://orcid.org/0000-0002-0817-9573
Suchkov Igor A., MD, Associate Professor, Vice-Rector for Research and Innovative Development, Professor of the Department of Cardiovascular, Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russian Federation.
http://orcid.org/0000-0002-1292-5452
Pshennikov Alexander S., PhD, Associate Professor, Dean of the Medical Faculty, Associate Professor of the Department of Cardiovascular, Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russian Federation. http://orcid.org/0000-0002-1687-332X
Vinogradov Sergey A., Clinical Intern of the Department of Cardiovascular, Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russian Federation.
http://orcid.org/0000-0001-8547-4798
Contacts | ©Vitebsk State Medical University, 2007