Novosti
Khirurgii
This journal is
indexed in Scopus









Year 2014 Vol. 22 No 2

GENERAL AND SPECIAL SURGERY

DOI: http://dx.doi.org/10.18484/2305-0047.2014.2.191   |  

L.M. CHERNUKHA1, E.V. KASHYROVA1, E.V. LUGOVSKOY2, S.V. KOMISARENKO2, I.N. KOLESNIKOVA2, E.M. MAKOHONENKO2, T.N. PLATONOVA2, L.V. PIROGOVA2, O.V. GORNICKAYA2

CHARACTERISTICS OF HEMOSTATIC SYSTEM STATE AT ARTERIOVENOUS FORMS OF CONGENITAL VASCULAR MALFORMATIONS

SE National Institute of Surgery and Transplantology named after O.O. Shalymov under NAMS of the Ukraine,1
A.V. Palladin Institute of Biochemistry of the National Academy of Sciences of the Ukraine2
The Ukraine

Objectives. To study the hemostatic system state in patients with diffuse arteriovenous forms of congenital vascular malformations (AVF CVM) based on the assessment of immunodiagnostic tests informativeness for determination of plasma coagulation and fibrinolysis systems activation degree aimed to forecast hemostasiological disturbances in the perioperative period.
Methods. The study results of plasma hemostasis system (D-dimer, soluble fibrin, fibrinogen) and fibrinolysis system (protein C) using immunodiagnostic tests in the preoperative and in the early postoperative periods (up to 3 days) in the main group patients with AVF CVM (n=23) and in the control group patients with varicose vein disease (n=16, clinical class 3-5, by CEAP) are presented in the article.
Results. In the preoperative period in 9 (43%) patients with AVF CVM, the imbalance manifested in a significant activation of coagulation capacity with normal activity of protein C was revealed. In 10 (62,5%) patients of the control group, a moderate activity of the coagulation capacity activation of hemostasis system at the normal activity of the fibrinolysis system (protein C) was established. The correlation between characteristics of coagulative and fibrinolytic potentials was observed in postoperative period in the main group, hypocoagulation in 4 (57%) patients; imbalance between characteristics of coagulation and fibrinolytic system (hypercoagulability) in 5 (45,5%) patients of the control group.
Conclusions. Diagnostic tests defining the state of coagulative and fibrinolytic systems are considered necessary to be done for timely correction of hemostasiological disturbances and for the prevention of fatal hemorrhagic complications in the perioperative period in patients with diffuse AVF CVM.

Keywords: congenital vascular malformations, arteriovenous forms, immunodiagnostic test-system, D-dimer, soluble fibrin, fibrinogen, protein C, balance, imbalance
p. 191 198 of the original issue
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Address for correspondence:
03680, Ukraina, g. Kiev, ul. Geroev Sevastopolia, d. 30, GU Natsional'nyi institut khirurgii i transplantologii im. A.A. Shalimova NAMNU, otdel khirurgii magistral'nykh sosudov,
e-mail: aristosha@list.ru,
Kashirova Elena Vladimirovna
Information about the authors:
Chernukha L.M. MD, a leading researcher of the main vessels department of SE National Institute of Surgery and Transplantology named after O.O. Shalymov under NAMS of the Ukraine, Kiev, the Ukraine.
Kashyrova O.V. A junior researcher of the main vessels department of SE National Institute of Surgery and Transplantology named after O.O. Shalymov under NAMS of the Ukraine, Kiev, the Ukraine.
Lugovskoy E.V. A corresponding member of NAS of the Ukraine, Dr.Sci.(Biol), professor, a head of the structure and function of protein department of A.V. Palladin Institute of Biochemistry of NAS of the Ukraine.
Komisarenko S.V. An academician of NAS and NAMS of the Ukraine, Dr.Sci.(Biol), professor, Director of A.V. Palladin Institute of Biochemistry of NAS of the Ukraine.
Makohonenko E.M. Dr.Sci.(Biol), a chief researcher of the structure and function of protein department of A.V. Palladin Institute of Biochemistry of NAS of the Ukraine.
Platonova T.M. Dr.Sci.(Biol), a leading researcher of the protein structure and function of protein department of A.V. Palladin Institute of Biochemistry of NAS of the Ukraine.
Pirogova L.V. A junior researcher of A.V. Palladin Institute of Biochemistry of NAS of the Ukraine.
Gornickaya O.V. PhD, a senior researcher of A.V. Palladin Institute of Biochemistry of NAS of the Ukraine.
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