Year 2021 Vol. 29 No 5




Avicenna Tajik State Medical University, Dushanbe,
The Republic of Tajikistan

This review is devoted to the relevance of the problem and the assessment of potential surgical indications, surgical methods and clinical results in the intestinal autotransplantation. Radical resection of the neoplasm is performed. Currently, the main indications for performing intestinal autotransplantation are considered neoplasms of the pancreas, mesenteric and retroperitoneal space with the involvement of the superior mesenteric vessels in the process. Preliminary results demonstrate that radical resection can be effective in carefully selected patients. Although perioperative morbidity and mortality are relatively high, the literature describes some cases with long patient survival, especially when performing radical resection of a benign tumor or a tumor of potential low malignant. However, early tumor recurrence remains a serious problem in patients with a high-grade tumor, especially with pancreatic ductal adenocarcinoma (PDAC). It should be noted that when using intestinal autotransplantation, it is possible to perform a radical resection of the organ in patients with separate neoplasms in the abdominal cavity and the involvement of the main mesenteric vessels in the process. However, this aggressive method is associated with significant operational risk and should be only performed in specialized centers. The additional combination therapies have to be developed to optimize the clinical outcome and prolong the survival of patients with pancreatic cancer.

Keywords: autologous transplantation, intestines, abdominal cavity, pancreatic cancer, mesenteric tumors
p. 607-616 of the original issue
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Address for correspondence:
734003, Republic of Tajikistan,
Dushanbe, Rudaki Avenue, 139.
Avicenna Tajik State Medical University,
the Department of Surgical Diseases No1,
tel.: +992 928-21-77-55,
Ali-Zade Sukhrob G.
Information about the authors:
Mukhabbatov Dzhiyonkhon K., MD, Professor of the Department of General Surgery No1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan.
Gulov Makhmadshokh K., MD, Professor of the Department of General Surgery No1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan.
Ali-Zade Sukhrob G., PhD, Associate Professor of the Department of Surgical Diseases No1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan.
Nozimov Farkhod H., PhD, Assistant of the Department of General Surgery No1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan.
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