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Year 2024 Vol. 32 No 1

SCIENTIFIC PUBLICATIONS

S.A. TACHYLA 1, 2, A.M. DZYADZKO 3, A.V. MAROCHKOV 1, 2, A.L. LIPNITSKI 1, 2, Y.G. POKHODNYA 4, O.P. SAVACHKA 4, V.A. LIVINSKAYA 5

CONCENTRATIONS OF TRACE ELEMENTS (COBALT, CHROMIUM, COPPER, SELENIUM, ZINC) IN PATIENTS WITH ABDOMINAL SEPSIS IN THE POSTOPERATIVE PERIOD

Healthcare institution “Mogilev Regional Clinical Hospital” 1, Mogilev,
Educational institution “Vitebsk State Medical University” 2, Vitebsk,
State Institution “Minsk Scientific and Practical Center for Surgery, Transplantology and Hematology” 3,
Healthcare institution “National Anti-Doping Laboratory” 4, Minsk,
Interstate educational institution of higher education “Belarusian-Russian University” 5, Mogilev,
Republic of Belarus

Objective. The aim of the study was to examine the dynamics of microelements (cobalt, chromium, copper, selenium, zinc) and the need for their correction in patients with sepsis and multiple organ failure syndrome (MODS) after abdominal surgery.
Methods. A prospective observational study was conducted in 45 patients who had surgical pathology of the abdominal organs requiring surgical treatment. All patients were divided into 2 groups: group 1 (n=18) – with the absence of sepsis and MODS; group 2 (n=27) – with the presence of sepsis and MODS. During the 1st day of admission to the anesthesiology and resuscitation department (1st stage), as well as on the 5th (2nd stage) and 10th day (3rd stage) from admission, venous blood was take for determination of cobalt, chromium, copper, selenium, zinc.
Results. The level of cobalt was statistically significantly reduced in group 1 compared to group 2 at all stages: in group 1 at stage 1 – 0.4 (0.27-0.66) μg/l, at the 2nd stage – 0.31 (0.24-0.44) µg/l, at the 3rd stage – 0.35 (0.26-0.61) µg/l. Chromium levels were within normal limits in all patients in the study groups. The copper content was statistically significantly lower in group 2 compared to group 1 at all stages: in group 2 at stage 1 – 819.3 (721.5-949) μg/l, at stage 2 – 1st stage – 825.2 (762.5-977.4) µg/l, 3rd stage – 819.7 (759.2-981.5) µg/l. Selenium levels were below normal in group 1: stage 1 – 52.3 (41.5-67.7) µg/l, stage 2 – 51.9 (38.8-63.7) µg /l, stage 3 – 54.8 (33.8-66) µg/l; and in the 2nd group: 1st stage – 47.6 (33.8-66.2) µg/l, 2nd stage – 57.5 (42.7-68.7) µg/l, 3 stage – 47.4 (40.2-57.8) µg/l. A decrease in zinc levels was noted in patients of both groups below normal in group 1: stage 1 – 5624.3 (4911.2-6293.5) mcg/l, stage 2 – 5709.7 (5057.6 -6038.7) µg/l, stage 3 – 5438.5 (4998.8-6168.7) µg/l; and in the 2nd group: 1st stage – 5298.7 (4554.3-6011.4) µg/l, 2nd stage – 5519.5 (4702.4-6315.4) µg/l, 3 stage – 5370.6 (4528.8-6014.8) µg/l.
Conclusion. Analysis of the dynamics of the level of concentrations of trace elements showed that the level of copper was lower and the level of cobalt was higher in patients with abdominal sepsis in the postoperative period compared with the comparison group.

Keywords: trace elements, cobalt, chromium, copper, selenium, zinc, sepsis, multiple organ dysfunction syndrome
p. 21-30 of the original issue
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Address for correspondence:
212016, Republic of Belarus,
Mogilev,Belynitskij-Biruli, st. 12,
Mogilev Regional Clinical Hospital,
Department of Anesthesiology and Reanimation,
tel.: +375 222 62-75-95,
e-mail: tsa80@inbox.ru,
Tachyla Siarhei A
Information about the authors:
Tachyla Siarhei A, PhD, Associate professor, Anesthesiologist-Resuscitator of the Department of Anesthesiology and Resuscitation, Mogilev Regional Clinical Hospital, Head of the Branch of the Departments of Anesthesiology and Resuscitation with a Course of FAK and PK and Hospital Surgery with a course of FAK and PK Vitebsk State Medical University «, Mogilev, Republic of Belarus.
https://orcid.org/0000-0003-1659-5902
Dzyadzko Alexander M., MD, Professor, Honored Doctor of the Republic of Belarus, Head of the Department of Anesthesiology, Resuscitation and Intensive Care, State Institution «MNPC KhTiG», Minsk, Republic of Belarus.
https://orcid.org/0000-0003-1965-1850
Marochkov Alexei V., MD of Medical Sciences, Professor, Anesthesiologist-Resuscitator of the Department of Anesthesiology and Resuscitation, Mogilev Regional Clinical Hospital, Professor of the Branch of the Departments of Anesthesiology and Reanimatology with a Course of FAK and PK and Hospital Surgery with a Course of FAK and PK Vitebsk State Medical University «, Mogilev, Republic of Belarus.
https://orcid.org/0000-0001-5092-8315
Lipnitski Artur L., PhD, Associate Professor, Anesthesiologist-Resuscitator, Head of the Department for Coordinating the Collection of Organs and Tissues for Transplantation, Mogilev Regional Clinical Hospital, Associate Professor of the Branch of the Departments of Anesthesiology and Resuscitation with a Course of FAK and PC and Hospital Surgery with a Course of FAK and PC EE «Vitebsk State Medical University», Mogilev, Republic of Belarus.
https://orcid.org/0000-0002-2556-4801
Pokhodnya Yury G., PhD (Biol), Associate Professor, Director of the National Anti-Doping Laboratory, Minsk, Republic of Belarus.
https://orcid.org/0009-0009-3898-255X
Savachka Aleh P., Master of Chemical Sciences, Chemist of the Department of Chemical-Toxicological Research of the National Anti-Doping Laboratory, Minsk, Republic of Belarus.
https://orcid.org/0000-0002-3952-4974
Livinskaya Viktoriya A., PhD, Associate Professor, Associate Professor of the Department of Finance and Accounting, Interstate Educational Institution of Higher Education «Belarusian-Russian University».
https://orcid.org/0000-0001-8953-8533
Contacts | ©Vitebsk State Medical University, 2007-2023