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Научно-практическая конференция с международным участием и
XXVIII Пленум Правления Белорусской ассоциации хирургов
«Актуальные вопросы и современные подходы в оказании
хирургической помощи в Республике Беларусь»
18-19 ноября 2021 года в г. Минск.

Year 2015 Vol. 23 No 1


DOI:   |  



ME "Mogilev Regional Hospital",
The Republic of Belarus

Objectives. To carry out the comparative evaluation of cisatracurium and atracurium as a component of a balanced endotracheal anesthesia for the abdominal laparoscopic surgeries.
Methods. 80 patients at the age of 18-70, who had undergone the laparoscopic cholecystectomy, were enrolled in the prospective randomized study. All patients received cisatracurium 0,1 mg / kg (the 1st group) or atracurium 0,3 mg / kg (the 2nd group). Monitoring of neuromuscular transmission is carried out according to Stockholm criteria of the pharmacodynamic studies of myorelaxants action.
Results. Cisatracurium administration (270 (225-330) had faster onset time of neuromuscular block in comparison with the 2nd – 390 (210-540) (p<0,01). In the 1st group intubation conditions were excellent in 28 (66,7%) cases, in the 2nd group – in 13 (34,2%) patients (p<0,05), and poor – in 3 cases (1st group), in 12 cases, (p<0,05) in the 2nd group. Duration of action of atracurium was reliably lower – 31,5 (25-37) min in comparison with cisatracurium – 43 (40-50) min (p<0,05). In atracurium group total number of complications / side effects was higher than in cisatracurium group, in 2nd group – 16 and 5 – in the 1st group (p<0,05). Serious complications related to regional anesthesia have not been observed.
Conclusion. Low doses of cisatracurium (0,1 mg/kg) cause faster onset and create better conditions for tracheal intubation, compared with that of atracurium. Cisatracurium (0,1 mg/kg) proved tо have a longer duration of action than atracurium (0,3 mg/kg).

Keywords: myorelaxants, cisatracurium, atracurium, neuromuscular block, general anesthesia, randomized controlled trial
p. 91-96 of the original issue
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Address for correspondence:
212002, Respublika Belarus,
g. Mogilev, ul. B. Biruli d. 12,
ME "Mogilev Regional Hospital",
otdelenie anesteziologii i reanimatsii,
tel. office: +375 222 278 733,
Lipnitski Artur Leonidovich
Information about the authors:
Lipnitski A.L. A head of the transplant-coordination department of ME "Mogilev Regional Hospital".
Marochkov A.V. MD, professor, a head of the anesthesia and intensive care department of ME "Mogilev Regional Hospital".
Contacts | ©Vitebsk State Medical University, 2007