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Khirurgii
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Year 2008 Vol. 16 No 2

ONCOLOGY

GIDRANOVICH A.V., KONEVALOVA N.YU., LUD N.G.

SATURATED FATTY ACIDS IN THE BLOOD SERUM IN BENIGN AND MALIGNANT MAMMARY TUMOURS

The influence of diet on different pathophysiological processes in the human organism is currently the point of interest. All nutritious substances, which are not synthesized in the human metabolism (including essential fatty acids) can possess direct or mediated regulatory effect on pathophysiological and biochemical processes. More than 30% of cancer cases can be linked with premorbid diet and fatty food consumption. Fatty acids are the components of membrane phospholipids and the precursors of multiple biological active substances. They participate in different regulatory processes including apoptosis and DNA expression regulation and therefore participate in oncogenesis and tumour progression. By now many mechanisms of interaction between cancer and fatty acids composition have been proposed. The aim of this investigation is to determine the fatty acids spectrum in healthy women, patients with benign mammary tumours and breast cancer. It has been determined that serum myristic acid content significantly decreases in benign and malignant breast tumours. Palmitic acid and stearic acid content is stable in investigated groups.

Keywords: breast cancer, saturated fatty acids.
p. 71 81 of the original issue
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