Year 2010 Vol. 18 No 6

GENERAL AND SPECIAL SURGERY

DOVNAR R.I., SMOTRIN S.M., VASILKOV A.YU., ZHMAKIN A.I.

ANTIBACTERIAL AND ANTIFUNGAL EFFECT OF THE BANDAGING MATERIAL CONTAINING SILVER NANOPARTICLES

Objectives. To study antibacterial and antifungal effect of the bandaging material on the basis of medical gauze bandage containing silver nanoparticles obtained by means of the metal vapor synthesis method.
Methods. In the research the strains of microorganisms and fungi of Candida genus were used which had been isolated from the purulent wounds of the surgical patients. Determination of the antibacterial and antifungal effect of the bandaging containing silver nanoparticles was performed on Petri dishes with agar. A usual medical gauze bandage was used for control. Sensitivity to antibiotics and antibacterial preparations had been previously revealed in these strains of microorganisms. The correlation analysis of antibacterial action of the bandaging containing silver nanoparticles was carried out as well as the analysis of microorganisms sensitivity to antibiotics.
Results. Medical gauze bandage containing silver nanoparticles was found out to have antibacterial and antifungal action. The performed correlation analysis showed that there was no any link between microbes resistance to antibiotics and resistance to silver nanoparticles.
Conclusions. Nanocomposite material silver/bandage has a marked antimicrobial action in relation to gram-positive and gram-negative bacteria and Candida. Microorganisms resistance to silver-containing bandaging doesnt correlate with the range and level of their sensitivity to antibiotics.

Keywords: silver nanoparticles, antibacterial and antifungal effect, medical gauze bandage
p. 3 11 of the original issue
References
  1. Schofield, W. C. A substrate-independent approach for bactericidal surfaces / W. C. Schofield, J. P. Badyal // ACS applied material & interfaces. 2009. Vol. 1, N 12. P. 2763-2767.
  2. , . . / . . . : , 2005. 150 .
  3. Silver, S. Bacterial heavy metal resistance: new surprises / S. Silver, L. T. Phung // Annual review of microbiology. 1996. Vol. 50. P. 753-789.
  4. Fox, C. L. Silver sulphadiazine a new topical therapy for pseudomonas in burns. Therapy of pseudomonas infection in burns / C. L. Fox // Archievs of surgery. 1968. Vol. 96, N 2. P. 184-188.
  5. Lansdown, A. B. Silver 2. Toxicity in mammals and how its products aid wound repair / A. B. Lansdown // Journal of wound care. 2002. Vol. 11, N 5. P. 173-177.
  6. Park, S. J. Preparation and characterization of activated carbon fibers supported with silver metal for antibacterial behavior / S. J. Park, Y. S. Jang // Journal of colloid and interface science. 2003. Vol. 261, N 2. P. 238-243.
  7. Designing surfaces that kill bacteria on contact / J. C. Tiller [et al.] // Proceedings of the national academy of science. 2001. Vol. 98, N 11. P. 5981-5985.
  8. Goldstein, A. N. Handbook of nanophase materials / A. N. Goldstein. New York: Marcel dekker inc., 1997. 370 .
  9. A versatile strategy to fabricate hydrogelsilver nanocomposites and investigation of their antimicrobial activity / V. Thomas [et al.] // Journal of colloid and interface science. 2007. Vol. 315, N 1. P. 389-395.
  10. Merisko-Liversidge, E. M. Drug nanoparticles: formulating poorly water-soluble compounds / E. M. Merisko-Liversidge, G. G. Liversidge // Toxicologic pathology. 2008. Vol. 36. P. 43-48.
  11. Chen, X. Nanosilver: a nanoproduct in medical application / X. Chen, H. J. Schluesener // Toxicology letters. 2008. Vol. 176, N 1. P. 1-12.
  12. Sun, T. Silver clusters and chemistry in zeolites / T. Sun, K. Seff // Chemical reviews. 1994. Vol. 94, N 4. P. 857-864.
  13. A silver colloid produced by reduction with hydrazine as support for highly sensitive surface-enhanced Raman spectroscopy / U. Nickel [et al.] // Langmuir. 2000. Vol. 16, N 23. P. 9087-9094.
  14. Fe-Au, - / . . [ .] // . . 2008. . 3, 1-2. . 76-81.
  15. Ultrahigh molecular weight polyethylene modified with silver nanoparticles prepared by metal-vapour synthesis / A. Vasilkov [et al.] // AIP Conference Proceeding. 2008. Vol. 1042. P. 255-257.
  16. / . . [ .] // : . . c. . .-. . , , 1920 2010 . , 2010. . 59-60.
  17. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus / Q. L. Feng [et al.] // Journal of biomedical materials research. 2000. Vol. 52, N 4. P. 662-668.
  18. The influence of platinum on the performance of silver-platinum antibacterial coatings / A. J. Betts [et al.] // Materials & Design. 2005. Vol. 26, N 3. P. 217-222.
  19. Effects of halides on plasmid-mediated silver resistance in Escherichia coli / A. Gupta [et al.] // Applied and environmental microbiology. 1998. Vol. 64, N 12. P. 5042-5045.
  20. Metal oxide nanoparticles as bactericidal agents / P. K. Stoimenov [et al.] // Langmuir. 2002. Vol. 18, N 17. P. 6679-6686.
Contacts | ©Vitebsk State Medical University, 2007-2023