Year 2012 Vol. 20 No 1




EE Belarusian State Medical University,
the Republic of Belarus

Objectives. Analysis of the nearest and distant treatment results of patients with thymomas; carrying out of pathomorphological estimation of the tumors and determination of dependence between the histological structure of the thymus tumors and general survival rate of patients.
Methods. 113 patients with the mediastinum tumors including 17 patients with the thymus tumors were included in the research.
Results. 7 patients (41,2%) died of the disease progressing. 3 patients in whom thymoma invasiveness was doubtful died of locoregional recurrence or the disease progressing in the form of separate metastases in different terms after treatment had been completed.
Conclusions. Benign process in the thymus which hasnt been proved at the intraoperative revision and an urgent morphological investigation should be regarded as malignant tumors when the radical volume of the surgical operation with the mediastinum lymphodissection should be performed.

Keywords: mediastinum tumors, thymus, thymomas
p. 89 92 of the original issue

1.Kaschiato D. Onkologiia [Oncology]. Brusov PG, editor (iseev , per s angl). Moscow, RF; 2008. 541 p.
2.Kharchenko VP. Bolezni vilochkovoi zhelezy [Diseases of thymus gland]. Moscow, RF; 1998. 129 p.
3.Ganul AV. Optimizatsiia diagnostiki i lecheniia patsientov so zlokachestvennymi opukholiami sredosteniia [Optimizing the diagnosis and treatment of patients with malignant tumors of the mediastinum]. Onkologiia. 2009;(2):13135.
4.Marino M, Muller-Hermelink HK. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of the thymus. Virchows Arch A Pathol Anat Histopathol. 1985;407(2):11949.
5. Tomaszek S, Wigle DA, Keshavjee S, Fischer S. Thymoms: review of current clinical practice. Ann Thorac Surg. 2009 Jun;87(6):197380.
6.Blumberg D, Port JL, Weksler B, Delgado R, Rosai J, Bains MS, Ginsberg RJ, Martini N, McCormack PM, Rusch V, et al. Thymoma: a multivariate analysis of factors predicting survival. Ann Thorac Surg. 1995 Oct;60(4):90813; discussion 914.
7.Kondo K, Monden Y. Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan. Ann Thorac Surg. 2003;76(3):87884; discussion 88485.
8.Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini E. Thymoma: results of 241 operated cases. Ann Thorac Surg. 1991 Jan;51(1):15256.
9.Nakahara K, Ohno K, Hashimoto J, Maeda H, Miyoshi S, Sakurai M, Monden Y, Kawashima Y. Thymoma: results with complete resection and adjuvant postoperative irradiation in 141 consecutive patients. J Thorac Cardiovasc Surg. 1988 Jun;95(6):104147.
10.Mornex F, Resbeut M, Richaud P, et al. Radiotherapy and chemotherapy for invasive thymomas: a multicentric retrospective review of 90 cases. The FNCLCC trialists. Federation Nationale des Centres de Lutte Contre le Cancer. Int J Radiat Oncol Biol Phys. 1995;32(3):65159.
11.Ciernik IF, Meier U, Lutolf UM. Prognostic factors and outcome of incompletely resected invasive thymoma following radiation therapy. J Clin Oncol. 1994;12(7):148490.
12.Kubota K, Yamada S, Kondo T, Yamada K, Fukuda H, Fujiwara T, Ito M, Ido T. PET imaging of primary mediastinal tumours. Br J Cancer. 1996 Apr;73(7):88286.
13.Liu RS, Yeh SH, Huang MH, Wang LS, Chu LS, Chang CP, Chu YK, Wu LC. Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of thymoma: a preliminary report. Eur J Nucl Med. 1995 Dec;22(12):1402407.
14.Sasaki M, Kuwabara Y, Ichiya Y, Akashi Y, Yoshida T, Nakagawa M, Murayama S, Masuda K. Differential diagnosis of thymic tumors using a combination of 11C-methionine PET and FDG PET. J Nucl Med. 1999 Oct;40(10):1595601.

Address for correspondence:
220116, Respublika Belarus', g. Minsk, pr-t. Dzerzhinskogo, d. 83, Belorusskii gosudarstvennyi meditsinskii universitet, kafedra onkologi,
Shepetko Mikhail Nikolaevich
Information about the authors:
Prokhorov A.V. Doctor of medical sciences, professor, head of the oncology chair of EE Belarusian State Medical University.
Shepetko M.N. Candidate of medical sciences, associate professor of the oncology chair of EE Belarusian State Medical University.
Labunets I.N. Candidate of medical sciences, assistant of the oncology chair of EE Belarusian State Medical University.
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