Novosti
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Year 2013 Vol. 21 No 1
EXPERIMENTAL SURGERY
R.A. MAMMADOV12
MORPHOLOGICAL ESTIMATION OF THE LOCAL REACTION OF AN ORGANISM AT APPLICATION OF MESH MATERIALS FOR PROSTHETICS OF ANTERIOR ABDOMINAL WALL
Azerbaijan Medical University, Baku1,
The Republic Azerbaijan
SBEE HPE “Kursk State Medical University” 2,
The Russian Federation
Objectives. To study the morphological changes in the anterior abdominal wall tissues in the fixation zone of the lavsan and polypropylene prosthesis.
Methods. Experimental investigations were made on 40 mice (20 animals in each series). The animals were subdivided into 2 groups: the 1st group – with the lavsan prosthesis use; in the 2nd group – with the polypropylene prosthesis. Histological examination of the muscular-aponeurotic fragments combined with the synthetic materials with staining of the preparations by hematoxylin and eosin and according to Van-Gizon method was conducted on the 10th, 30th and 60th day.
Results. While performing the comparative analysis of the macrophage reaction in the connective tissue, significantly more number of macrophages in the surrounding connective tissue were registered at the lavsan prosthesis implantation between two groups of animals that testified to more «foreignness» of the given material.
In comparison of the segmented leukocytes dynamics in the 2nd group we found out a reliable decrease of the leukocytes number at the percentage ratio stabilization of fibroblasts and macrophages versus the earlier terms that proved the reduction of the inflammatory process intensity as well as intensification of the repair processes.
In both series of the experiment the lymphocytic reaction analysis indicated the growth of the immune response in terms up to 1 month with its subsequent reduction in the 1st group and the stable manifestation in the 2nd group.
The particular significance is considered to be a comparative characteristics of a fibroblastic reaction as a mechanism of formation of protective fence off capsule of the “foreign” body which is in fact any endoprosthesis.
The research showed a stable formation of the connective tissue in the 2nd group. In the case when the lavsan endoprosthesis is used the formation of the connective-tissue capsule has delayed caused by the inflammatory processes.
Conclusions. On the basis of the conducted experiment the low biocompatibility of the lavsan prosthesis was established in comparison with the polypropylene prosthesis. Therefore the use of polypropylene implant is considered to be preferable in clinical practice.
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AZ1065, Respublika Azerbaidzhan, g. Baku, ul. Bakikhanova, d. 23, Azerbaidzhanskii meditsinskii universitet, kafedra khirurgicheskikh boleznei ¹ 3,
e-mail: rmamedov2001@yahoo.com,
Mamedov Ruslan Aidyn ogly
Mammadov R.A. PhD, assistant of the surgical diseases chair ¹ 3 of Azerbaijan Medical University, post-graduate student of the surgical diseases chair ¹ 1 (2007 – 2009 years) of SBEE HPE “Kursk State Medical University”.
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