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Khirurgii

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Year 2014 Vol. 22 No 3

GENERAL AND SPECIAL SURGERY

E.A. MATUSEVICH

THE CORRECTION FOR IMMUNOGLOBULIN AND INTERLEUKIN STATUS IN PATIENTS WITH GENERALIZED PURULENT PERITONITIS

ME “Braslav Central District Hospital”,
EE “Vitebsk State Medical University”,
The Republic of Belarus

Objectives. To study the immunoglobulin and interleukin status in patients with generalized purulent peritonitis in the postoperative period and the ways of its correction by means of citoflavin, the drug containing succinic acid.
Methods. The treatment analysis of 26 patients divided into 2 groups with generalized purulent peritonitis has been performed. The control group (n=12) received a conventional complex treatment and the main group (n=14) received additionally the drug citoflavin. Influence of citoflavin the combined drug containing succinic acid on the levels of immunoglobulins and interleukins in the blood serum of patients with generalized purulent peritonitis has been studied. The concentration of IgG, IgÌ, general IgÀ, secretory IgÀ, TNFa (tumor necrosis factor), IL-1β, IL-4, IL-6, IL in the blood serum were determined by solid-phase enzyme immunoassay.
Results. The expressed changes of immune system characterized by the increase of the secretory IgÀ and TNFa concentration as well as the reduction of IgM, IgG and general IgA levels in the blood serum are registered in patients with generalized purulent peritonitis in the postoperative period. From 1st day of post-operative period the increase of the concentration of both pro-inflammatory (IL-1β, IL-6, IL-8) and anti-inflammatory (IL-10) interleukins on the background of reduction of regulatory mediators (IL-2, IL-4) level has been established. On the 5-7th days those changes have remained testifying to continuing phenomena of the systemic inflammation in conventional therapy whereas in the group where the patients who received citoflavin the study parameters appears to be close to normal.
Conclusions. Including in the complex treatment of patients with generalized peritonitis of the drug containing succinic acid (citoflavin) promotes to normalization of immunoglobulin and interleukin profiles of the blood in the early postoperative period that indicates to the possibility of its application as a metabolic immunoregulator.

Keywords: generalized purulent peritonitis, interleukins, immunoglobulins, citoflavin
p. 326 – 331 of the original issue
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Address for correspondence:
211970, Respublika Belarus, Vitebskaya oblast, g. Braslav, ul. Sovetskaya, d. 138, UZ «Braslavskaya tsentralnaya rayonnaya bolnitsa»,
e-mail: burat@km.ru,
Matusevich Evgeniy Anatolevich
Information about the authors:
Matusevich E.A. Deputy Physician on medical affairs of ME “Braslov CDH”, applicant of the hospital surgery chair with urology and pediatric surgery of EE “Vitebsk State Medical University”.
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