Novosti
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This journal is indexed in Scopus |
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Year 2018 Vol. 26 No 5
SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY
V.D. SHYSHCHUK1, S.I. REDKO1, M.N. OGIENKO2, D.V. OVECHKIN1, L.V. TOMIN1
DISTURBANCES OF REPARATIVE OSTEOGENESIS IN THE HYPOVOLEMIA AND THEIR CORRECTION IN EXPERIMENT
Sumy State University 1,
Sumy City Clinical Hospital №5 2, Sumy,
Ukraine
Objective. To study reparative osteogenesis features in a long tubular bone of rats with moderate isoosmolar dehydration and the determination of the possibility to correlate the morphofunctional changes, caused by dehydration using the drug Actovegin.
Methods. In male Wistar rats in the control (n=21) and experimental (n=21) groups, the trauma was simulated by applying a perforated defect in the middle third of the both tibia bones diaphysis. Moderate dehydration was achieved by total water deprivation for 6-7 days until 6-10% animal weight loss was reached. In the experimental group, Actovegin was administered 2 mg intramuscularly every other day. The introduction of the drug began immediately after the injury and continued until the end of the experiment. On the 3rd, 15th and 24th day, histological examination, morphometry and scanning electron microscopy was carried out to study morphological changes in rat tibial reclaims.
Results. Moderate isoоsmolar dehydration caused a disruption of cellular and tissue balance which slowed down the bone regeneration process without changing the staging of their course. As a result, a normal bone callus did not have time to form in expected terms. Actovegin stimulated the reparative bone regeneration, the ratio of tissue components of the regenerate changed, the area increased and the qualitative properties of coarse-fiber and lamellar bone tissues were improved in comparison with the indices of animals in the control group. An increase in the total area and diameter of the vessels in the regenerate was registered.
Conclusions. The use of the drug Аctovegin permitted to optimize the blood circulation in the damaged segment and to accelerate the processes of bone restructuring and maturation resulting in the formation of a full-blown bone callus.
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40018, Ukraine,
Sumy, Sanatornaya Str., 31,
Medical Institute of Sumy State University,
Department of Orthopedics
and Traumatology,
Tel. mob.: 380 066 08 27 869,
e-mail: redko-03@ukr.net,
Sergiy I. Redko
Shyshchuk Volodymir D., MD, Professor, Head of the Department of Orthopedics and Traumatology of Medical Institute, Sumy State University, Sumy, Ukraine.
https://orcid.org/0000-0003-3077-5651
Redko Sergiy I., Assistant of the Department of Orthopedics and Traumatology of Medical Institute, Sumy State University, Sumy, Ukraine.
https://orcid.org/0000-0001-8711-0429
Ogienko Maksym N., PhD, Physician, Sumy City Clinical Hospital №5, Sumy, Ukraine.
https://orcid.org/0000-0002-3208-4160
Ovechkin Denys V., PhD, Associate Professor of the Department of Orthopedics and Traumatology of Medical Institute, Sumy State University, Sumy, Ukraine.
https://orcid.org/0000-0003-1969-9272
Tomin Lubov V., Post-Graduate Student of the Department of Orthopedics and Traumatology of Medical Institute, Sumy State University, Sumy, Ukraine.
https://orcid.org/0000-0002-7239-6388
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