Novosti
Khirurgii

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Year 2018 Vol. 26 No 5

GENERAL & SPECIAL SURGERY

R.E. KALININ, I.A. SUCHKOV, N.D. MZHAVANADZE, E.A. KLIMENTOVA, O.N. ZHURINA, S.A. ISAKOV

INTRINSIC COAGULATION CASCADE FACTORS AND HEMOSTATIC MARKERS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan,
The Russian Federation

Objective. To assess the activity of intrinsic coagulation cascade factors of coagulation and hemostatic markers of endothelial dysfunction in patients with atherosclerotic peripheral artery disease (PAD) before and after endovascular treatment.
Methods. The study included 80 patients with PAD in the stage IIB-III of the disease according to Pokrovsky-Fontaine classification. 40 patients with PAD underwent endovascular interventions on the femoropopliteal segment (group A) and 40 patients underwent the conservative treatment (group B). Patients underwent physical examination, ankle-brachial index measurement (ABI), duplex ultrasound (DUS) and digital substraction angiography. 3 and 6 months after treatment patients underwent the same procedures. At inclusion of patients in the study and 3 months after the surgery, peripheral venous blood samples were collected to assess the activity of VIII, IX, XI, von Willebrand factor (VWF), protein С (PrC) and metabolites of nitric oxide II (NO).
Results. In patients of the group А mean values of activity VIII, IX, XI factors and VWF were increased in comparison with the norm before the surgery. After 3 months the results shown a greater increase in activity VIII, IX, XI factors, the elevated levels of VWF remained in the reduction of NO metabolites. In patients of the group B the mean activity values of IX, XI factors and VWF were increased with normal levels of NO metabolites and PrC.
Conclusions. The analysis of the initial state of the hemostasis system in patients with atherosclerotic peripheral artery disease allows us to conclude that the hypercoagulable state develops against the background of a normal anticoagulation potential. Operative procedures provide a further shift towards a hypercoagulable state and impaired functional activity of endothelium

Keywords: atherosclerosis, intrinsic coagulation cascade, hemostatic markers of endothelial dysfunction, nitric oxide II, von Willebrand factor
p. 547-554 of the original issue
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Address for correspondence:
390026, The Russian Federation,
Ryazan, Vysokovoltnaya Str., 9,
Ryazan State Medical University
Named after Academician I.P. Pavlov,
Department of Cardiovascular,
X-Ray Endovascular,
Operative Surgery
And Topographic Anatomy,
Tel. mobile: +7 4912 46 08 03,
e-mail: Suchkov_med@mail.ru,
Igor A. Suchkov
Information about the authors:
Kalinin Roman E., MD, Professor, Rector, Head of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-0817-9573
Suchkov Igor A., MD, Associate Professor, Vice-Rector for Research and Innovative Development, Professor of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-1292-5452
Mzhavanadze Nina J., PhD, Assistant of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0001-5437-1112
Klimentova Emma A., Post-Graduate Student of the Department of Cardiovascular, X-Ray Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0003-4855-9068
Zhurina Olga N., PhD, Head of Clinical and Diagnostic Laboratory of the Clinical Research Center for Hematology, Oncology and Immunology, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-6120-4678
Isakov Sergey A., MD, Professor of the Dermatovenereology Department, Ryazan State Medical University named after Academician I.P. Pavlov, Ryazan, Russian Federation.
http://orcid.org/0000-0002-0694-1309
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