Novosti
Khirurgii

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Year 2019 Vol. 27 No 3

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

V.A. LIPATOV 1, S.V. LAZARENKO 1, A.N. BETZ 2, D.A. SEVERINOV 1

CHANGES OF PHYSICO-MECHANICAL PROPERTIES OF VASCULAR PATCHES IN CONDITIONS OF CHRONIC EXPERIMENT IN VIVO

Kursk State Medical University 1,
Kursk Regional Hospital 2, Kursk,
The Russian Federation

Objective. To study the changes of the physical and mechanical properties of the vascular patch canvas (breaking load and tensile elongation at uniaxial tension) in the conditions of a chronic experiment in vivo.
Methods. New samples of vascular patches based on polyethylene terephthalate (PETP) fibers were used for experimental studies. In the group 1 – warp-knitted canvas based on polyethylene terephthalate fibers was used; in the group 2 – woven canvas based on polyethylene terephthalate and fluoronone, additionally impregnated with gelatin; the group 3 – warp knitted canvas based on polyethylene terephthalate fibers, developed by the group of the authors. As a comparison group, the results of the study of the same samples of vascular patches, non-implanted into the tissue of laboratory animals were used.
As the object for implantation, 60 male rats of Wistar line were chosen. Rats were divided into 3 groups (20 in each) according to the number of types of experimental samples and within each group into subgroups (10 according to the time of elimination from the experiment: 15 and 30 days). The test samples were implanted in the paravertebral region to the laboratory animals. Testing of physical-mechanical characteristics was carried out according to standard methods for assessing the strength characteristics using a tensile testing machine REM-0.2-1. The elongation (%) of the implant canals after implantation at 8 N, 16 N was evaluated, the breaking load (N) was recorded.
Results. Samples of vascular patches of polyethylene terephthalate, which do not have additional treatment with gelatin in the production process (group 3), withstood the greatest breaking load - 147 N (on the 15th day of the experiment) and 151 N (30 day), respectively. The percentage of their elongation was from 6% to 49%. In the case of samples with gelatin treatment, it was 66, 5 N and 75 N.
Conclusions. The values of the indices of the studied parameters of the physical mechanical properties of polymeric vascular implants after implantation to laboratory animals are higher in the samples of the group 3 during all periods of the experiment (15 and 30 days).

Keywords: vascular patches, chronic experiment, bursting machine, extensibility, polyethylene terephthalate, implants, vascular surgery
p. 249-255 of the original issue
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Address for correspondence:
305041, The Russian Federation,
Kursk, Karl Marks Str., 3,
Kursk State Medical University,
Department of Operative Surgery
and Topographic Anatomy,
Tel: +7 920 262-15-55,
e-mail: dmitriy.severinov.93@mail.ru,
Dmitriy A. Severinov
Information about the authors:
Lipatov Viacheslav A., MD, Associate Professor, Professor of the Department of Operative Surgery and Topographic Anatomy, Kursk State Medical University, Kursk, Russian Federation.
http://orcid.org/0000-0001-6121-7412
Lazarenko Sergey V., PhD, Assistant of the Oncology Department, Kursk State Medical University, Kursk, Russian Federation.
http://orcid.org/0000-0002-7200-4508
Betz Alexander N., Cardiovascular Surgeon, Kursk Regional Hospital, Kursk, Russian Federation.
https://orcid.org/0000-0001-6115-1812
Severinov Dmitriy A., Assistant of the Department of Operative Surgery and Topographic Anatomy, Kursk State Medical University, Kursk, Russian Federation.
http://orcid.org/0000-0003-4460-1353
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