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Khirurgii

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Year 2023 Vol. 31 No 5

SCIENTIFIC PUBLICATIONS

E.A. TONEEV, R.F. SHAGDALEEV, O.V. PIKIN, A.A. MARTYNOV, O.V. MIDLENKO, G.R. CHUKANOVA

FREQUENCY AND INDICATORS OF PROLONGED PLEURISY DEVELOPMENT AFTER LOBECTOMY FOR LUNG CANCER

Ulyanovsk Regional Clinical Oncologic Dispensary,
Ulyanovsk State University, Ulyanovsk,
Moscow Research Institute of Oncology named after P.A. Herzen - branch. P.A. Herzen Oncology Research Institute - branch of FGBU "National Medical Research Center of Radiology",
Ministry of Health of Russia, Moscow,
Russian Federation

Objective. To identify prognostic factors associated with prolonged postoperative pleural effusion after lobectomy for lung cancer.
Methods. The study was conducted on the base of the surgical department of thoracic oncology of the State Budgetary Healthcare Institution «Oncology Clinical Dispensary» in Ulyanovsk. The analysis included patients who underwent lobectomy with ipsilateral mediastinal lymph node dissection from March 01, 2023, to November 10, 2023. A total of 111 surgical interventions were performed; 66 patients were excluded from the study. 45 patients were included in the study, 23 of whom had no prolonged pleural effusion, and 22 patients experienced prolonged postoperative pleural effusion. Characteristics of the study participants were assessed using a standardized protocol.
Results. The frequency of prolonged pleural effusion development was 22/45 (48.9%). In conducting a multifactorial analysis of the probability of prolonged pleural effusion development, two statistically significant indicators were identified: «neutrophil-leukocyte index on the 5th day» and «protein in drainage fluid on 2nd day.» Threshold values for these parameters were determined: for the protein in drainage fluid on the 2nd day – 32.1 g/L, for the neutrophil-leukocyte index on the 5th day – 2.889. Beyond these threshold values, the risk of developing prolonged pleuritis statistically increased (p<0.001).
Conclusion. The frequency of prolonged pleuritis development was 22/45 (48.9%). Multifactorial analysis revealed statistically significant criteria: the neutrophil-leukocyte index on the 5th day and the protein quantity in pleural fluid on the 2nd day. When these values exceed the threshold, the risk of prolonged pleuritis development in patients increases (p<0.001).

Keywords: prolonged pleurisy, lung cancer, lobectomy, lung resection
p. 351-361 of the original issue
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Address for correspondence:
432017, Russian Federation,
Ulyanovsk, 12, September st. 90,
Regional State Health Institution
Clinical Oncology Dispensary,
tel. +79084731198,
e-mail: e.toneev@inbox.ru,
Toneev Evgeniy A.
Information about the authors:
Toneev Evgeniy A., PhD, Thoracic Surgeon of the Surgical Department of Thoracic Oncology of the State Healthcare Institution Regional Clinical Oncology Dispensary of Ulyanovsk, Associate Professor of the Department of Faculty Surgery, Faculty of Medicine named after T.Z. Biktimirova, Institute of Medicine, Ecology and Physical Culture, Ulyanovsk State University, Ulyanovsk, Russian Federation.
https://orcid.org/0000-0001-8590-2350
Shagdaleev Roman F., Resident of the Department of Hospital Surgery, Anesthesiology, Resuscitation, Urology, Traumatology And Orthopedics, Faculty of Dentistry, Pharmacy and Postgraduate Medical Education, Institute of Medicine, Ecology and Physical Culture, Federal State Budgetary Educational Institution of Higher Education Ulyanovsk State University, Ulyanovsk, Russian Federation
https://orcid.org/0009-0004-0218-666X
Pikin Oleg V., MD, Professor, Head of the Thoracic Surgical Department, Moscow Oncological Institute named after. P.A. Herzen – Branch of the Federal State Budgetary Institution «National Medical Research Center of Radiology» of the Ministry of Health of Russia, Moscow, Russian Federation
https://orcid.org/0000-0001-6871-6804
Martynov Alexander A., Thoracic Surgeon, Head of the Surgical Thoracic Department of the State Healthcare Institution, Ulyanovsk, Russian Federation
https://orcid.org/0000-0003-4662-9886
Midlenko Oleg V., MD, Professor of the Department of Hospital Surgery, Ulyanovsk State University. Ulyanovsk, Russian Federation.
https://orcid.org/0000-0001-8076-7145.
Chukanova Gulfiya R., Physician of Clinical Laboratory Diagnostics, Head of Laboratory, State Health Institution Regional, Clinical Oncology Dispensary , Russian Federation
https://orcid.org/0009-0005-7020-8522
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