Year 2024 Vol. 32 No 1

SCIENTIFIC PUBLICATIONS

D.V. OSIPENKO 1, V.V. KRIVENCHUK 2, A.V. MAROCHKOV 3, H.D. ASIPENKA 2

ENDOCRINE-METABOLIC MONITORING DURING CARDIAC SURGERY UNDER GENERAL MULTICOMPONENT ANESTHESIA

Gomel Regional Clinical Cardiology Center 1,
Gomel State Medical University 2, Gomel,
Mogilev Regional Clinical Hospital 3, Mogilev,
Republic of Belarus

Objective. To determine the dynamics of changes in cortisol, prolactin, and thyroid-stimulating hormone (TSH) during cardiac surgery with artificial circulation under general multicomponent endotracheal anesthesia and to assess their potential use as markers of endocrine monitoring.
Methods. The study included 30 patients who underwent planned cardiac surgery under artificial circulation. For anesthesia maintenance, general multicomponent endotracheal anesthesia based on sevoflurane (before and after artificial circulation), propofol (during artificial circulation), fentanyl, and pipecuronium were used. For endocrine-metabolic monitoring, cortisol, prolactin, and TSH in blood serum were controlled at the stages of the study: before the onset of the operation (1st stage), 15 minutes before the start of artificial circulation (5th stage), and after suturing the skin (7th stage).
Results. Cardiac surgeries with artificial circulation under general multicomponent endotracheal anesthesia are accompanied by endocrine changes at the 5th and 7th stages of the study in the form of an eleration in the level of cortisol (by 1.6 (1.1; 1.9) and 2.6 (2.1; 3.7) times), prolactin (by 2.7 (1.4; 4.1) and 3 (1.6; 4.9) times) and TSH (by 1.2 times (1.0; 1.9) and 1.2 (0.9; 1.9) times)? respectively.
Conclusion. Indicators of endocrine-metabolic monitoring of cortisol, prolactin, glucose, and lactate characterize the effectiveness of patient analgesia during cardiac interventions with artificial circulation.

Keywords: cortisol, prolactin, thyroid-stimulating hormone, cardiac surgery, artificial circulation, general anesthesia, analgesia
p. 5-12 of the original issue
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  • Address for correspondence:
    246046, Republic of Belarus,
    Gomel, Meditsinskaya st., 4,
    Institution «Gomel Regional
    Clinical Cardiology Center»,
    Department of Anesthesiology
    and Intensive Care with Intensive Care Wards,
    tel./fax: + 375 29 6146598,
    e-mail: osipenko081081@mail.ru,
    Osipenko Dmitry V.
    Information about the authors:
    Osipenko Dmitry V., PhD, Assistant at the Department of Surgical Diseases No. 1 with a Course in Vascular Surgery, Gomel State Medical University. Anesthesiologist-resuscitator (Head) of the Department of Anesthesiology and Intensive Care with Intensive Care Wards, Gomel Regional Clinical Cardiology Center, Gomel, Republic of Belarus.
    https://orcid.org/0000-0003-4838-1140
    Krivenchuk Vadim V., 4th Year Student of the Faculty of Medicine, Gomel State Medical University, Gomel, Republic of Belarus.
    https://orcid.org/0009-0001-6594-4569
    Osipenko Georgy D., 1st Year Student of the Faculty of Medicine, Gomel State Medical University, Gomel, Republic of Belarus.
    https://orcid.org/0009-0006-2059-4987
    Marochkov Alexey V., MD, Professor, Anesthesiologist-Resuscitator, Head of the Scientific and Practical Department of the Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus.
    https://orcid.org/0000-0001-5092-8315
    Contacts | ©Vitebsk State Medical University, 2007-2023