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Year 2018 Vol. 26 No 2

REVIEWS

A.M. FEDORUK

PERFUSION CONDITIONING OF THE LIVER AND KIDNEY ALLOGRAFTS

The Republican Scientific and Practical Center for Organ and Tissue Transplantation,
9th Municipal Clinical Hospital of Minsk,
The Republic of Belarus

Transplantation is the only radical treatment method of terminal stage liver and kidney diseases. Therefore, there has been an increase in the number of transplantations of these organs all over the world and in our country in recent decades. Transplantation success is due to the quality of the donor organ, the clinical status of the recipient before the operation, the time of warm and cold ischemia, the transplantation operation to the recipient, and immunological aspects, but particular importance is attaching to ischemic-reperfusion injury. Static cold preservation determines the development of the ischemia-reperfusion injury of allografts and its severity determines the outcome of the postoperative period.
The review highlights the current state of various variants of machine perfusion of the liver and kidneys. Renewal of interest to perfusion technologies is related to their ability to prevent the ischemia-reperfusion damage, which can be especially important when using donor organs with extended inclusion criteria, the so-called marginal allografts. Hypothermic machine perfusion, subnormothermic machine perfusion, normothermic machine perfusion, controlled heating are used nowadays. The parameters of the perfusion flow of the liver and kidneys were studied. At present, the clinical and economic effectiveness of only hypothermic renal perfusion has been proven. At the same time, the standards of machine perfusion and the protocols of its application are not fully developed and further studies are required.

Keywords: allografts, reperfusion injury, liver, kidney, conditioning methods, perfusion
p. 215-225 of the original issue
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Address for correspondence:
220045, The Republic of Belarus,
Minsk, Semashko Str., 8,
Republican Scientific and Practical
Center for Organ and Tissue Transplantation,
9th Municipal Clinical Hospital, Department of Hepatology and Minimally Invasive Surgery,
Tel.:+375 29 675 12 57,
e-mail: doctorfam@mail.ru,
Fedaruk Aliaksei M.
Information about the authors:
Fedaruk Aliaksei M., MD, Associate Professor, Head of the Department of Hepatology and Minimally Invasive Surgery of Republican Scientific and Practical Center for Organ and Tissue Transplantation, 9th Municipal Clinical Hospital, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-9211-8396
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