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Year 2018 Vol. 26 No 2

REVIEWS

YU.P. ORLOV 1, V.V. AFANAS’EV 2

HYPOXIA AND HYPEROXIA IN ANESTHESIOLOGIST-REANIMATOLOGIST PRACTICE. THE ROLE OF SUCCINATES IN CRITICAL CONDITIONS

Omsk State Medical University1, Omsk,
North-Western State Medical University named after I.I. Mechnikov 2, St. Petersburg,
The Russian Federation

The aim of the review was to analyze the potentially negative effects of hyperoxia in different groups of critically ill patients, including those after the heart arrest, craniocerebral trauma, stroke, and in cases of sepsis. It was found out that in case of these pathological processes and nosological forms, there is evidence that hyperoxia can have a direct and indirect damaging effect. A severe consequence of hyperoxia is not only activation of free radical oxidation and excessive synthesis of active oxygen forms, but also direct toxic damage to the lungs, which is associated with the development of atelectasis, tracheobronchitis and interstitial fibrosis. Hyperoxia can cause damage to any tissues and organs through peripheral vasoconstriction, which is extremely unfavorable for patients after heart arrest, after a craniocerebral trauma and stroke, as well as in septic patients.
The survey data emphasize that, taking into account individual adaptation to hypoxia, oxygen must be used individually, in accordance with the assessment of the current need for it. When using hyperoxia in patients in critical condition, it is possible to reduce the toxic effect of oxygen with the help of succinates, which support the mechanism of adaptation to hypoxia, and which have an antioxidant and antihypoxic effects. When carrying out oxygen therapy, it is necessary to avoid high concentrations of oxygen as much as possible, and in cases requiring high concentrations, to reduce the toxic effects of oxygen with the help of succinates.

Keywords: hypoxia, hyperoxia, succinates, heart arrest, trauma, stroke, sepsis
p. 226-237 of the original issue
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Address for correspondence:
644119, The Russian Federation,
Omsk, Perelet Str., 9
City Clinical Emergency Hospital № 1,
Department of Anesthesiology
and Reanimatology,
Omsk State Medical University,
Tel. +381-2-75-32-64,
е-mail: orlov-up@mail.ru,
Orlov Yurij P.
Information about the authors:
Orlov Yurij P., MD, Professor of the Department of Anesthesiology and Reanimatology, Omsk State Medical University, Omsk, Russian Federation.
http://orcid.org/0000-0002-6747-998X
Afanas’ev Vasilij V., MD, Professor of the Department of Emergency Medicine, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russian Federation.
http://orcid.org/0000-0001-6504-8169
Contacts | ©Vitebsk State Medical University, 2007-2023