Novosti
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This journal is indexed in Scopus |
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Year 2022 Vol. 30 No 2
GENERAL & SPECIAL SURGERY
I. V. MAKAROV, N. A. PROKOFIEVA, A.Y. SIDOROV, V.M. GOLUBOVA
METHODS FOR LABORATORY INTEGRATED ASSESSMENT OF PHOSPHORUS AND CALCIUM METABOLISM IN PRIMARY HYPERPARATHYROIDISM DIAGNOSIS
Samara State Medical University, Samara,
Russian Federation
Objective. To develop the methods for laboratory integral assessment of phosphorus-calcium metabolism to obtain reliable information about the functional state of the parathyroid glands (PTG), the probable presence or absence of primary hyperparathyroidism (PHPT) and monitoring the effectiveness of the treatment.
Methods. The study included the examination of 70 patients with PHPT (the first group) and 19 healthy volunteers (the second group). There were 59 (84%) women, 11 (16%) of men in the first group, the average age was 59±12.6 years (M±σ). This group was divided into two equal subgroups: 1A and 1B. In the first group (prior and after surgery) and in the second one, two indicators were calculated: IPHPT and CaPHPT. IPHPT was determined in 1A subgroup and in the second group as the ratio of the product of phosphorus and total calcium to parathyroid hormone (PTH); CaPHPT was calculated in the second group and in the subgroup 1B as the ratio of the product of phosphorus and ionized calcium to PTH. The presence or absence of adenomas of the PTG was confirmed by ultrasound examination of the neck, and, in the case of necessary, PTG scintigraphy, MRT of the neck.
Results. During the determination of IPHPT in the subgroup 1A prior surgery, it was found that its values varied from 0.037 to 2.46 (1.12±0.83); in the second group – from 3.35 to 9.5 (5.6±1.99) (M±σ). On determining CaPHPT in the subgroup 1B prior surgery, it was established that its values varied from 0.017 to 1.95 (0.52±0.36); in the second group – from 2.88 to 6.34 (3.86±1.27). In the first day after the removal of PTG adenomas the average values of indices approached values of healthy people of the second group: IPHPT in the subgroup 1A was 9.7±5.68, and CaPHPT in the subgroup 1B was 3.30±3.34, thus confirmed the effectiveness of the operation.
Conclusion. The proposed methods for laboratory integral assessment of phosphorus calcium metabolism are reliable quantitative assessments of the function in PTG. The values of IPHPT ≥ 2.46 and CaPPHPT > 1.95 indicate the absence of pathology in PTG. The values of IPHPT ≤ 2.46 and CaPHPT ≤ 1.95 indicate the presence of PHPT.
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443099, Russian Federation,
Samara, Chapaevskaya Str., 89,
Samara State Medical University,
Department of Surgery
of the Institute of Pediatrics,
tel. +79033342259,
e-mail: i.v.makarov@samsmu.ru,
Makarov Igor V.
Makarov Igor V., MD, Professor, Head of the Department of Surgery of the Institute of Pediatrics, Samara State Medical University, Samara, Russian Federation.
https://orcid.org/0000-0002-1068-3330
Prokofeva Natalia A., Assistant of the Department of Surgery of the Institute of Pediatrics, Samara State Medical University, Samara, Russian Federation. https://orcid.org/0000-0001-7620-6724
Sidorov Aleksandr Yu., Associate Professor of the Department of Surgery of the Institute of Pediatrics, Samara State Medical University, Samara, Russian Federation.
https://orcid.org/0000-0003-3613-4863
Golubova Valentina M., Clinical Intern of the Department of Surgery of the Institute of Pediatrics, Samara State Medical University, Samara, Russian Federation.
https://orcid.org/0000-0003-3510-2763
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