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Year 2015 Vol. 23 No 3

REVIEWS

I.V. MAIBORODIN, 1, S.E. KRASILNIKOV2, A.E. KOZJAKOV2, E.V. BABAYANTS2, A.P. KULIDZHANYAN2

THE FEASIBILITY OF TUMOR-RELATED ANGIOGENESIS STUDY AS A PROGNOSTIC FACTOR FOR CANCER DEVELOPMENT

FSBES "Institute of Chemical Biology and Fundamental Medicine", of SB of RAS, Novosibirsk1,
SBEE HPE "Novosibirsk State Medical University" 2
The Russian Federation

Objectives. To study a scientific literature review devoted to tumor-related angiogenesis and peculiarities of malignant tumors vascularization.
Methods. The analysis of about 50 foreign literature publications has been carried out.
Results. Numerous and often inconsistent results of studies specify that vascularization of malignant tumors can be considered to be an independent prognostic factor of a cancer progression, its invasion, appearance of local and distant metastases. Also there are a lot of publications calling into question a significance of the tumor angiogenesis as a predictor of tumor aggressiveness. The existence of the questionable publications containing statistically doubtful data with the improper interpretation of the received results should be mentioned. Only a few papers indirectly devoted to an angiogenesis in the distant organs and tissues were found.
Conclusion. The changes of tumor vascularization happen as a result of influence of various factors and releases produced by both cancerous cells and surrounding tissues at their hypoxia. All these cytokines and, partially, cellular elements are disseminated throughout the whole body and also have to manifest their pro- and antiangiogenic effect in the distant organs and tissues. Therefore, studying of angiogenesis in the places, distant from a tumor node, determination and specification of the predictors of intensity of a cancer progression and appearance of metastases, effectiveness of treatment and prospect of recurrence seems to be expedient. It is not excluded that analyzing vascularization changes, (for example, a skin), the prediction of angiogenesis intensity in the primary tumor and assessment of the main pathology prediction and effectiveness of the treatment will be possible in future.

Keywords: angiogenesis, pathology, hypoxia, tumor vascularization, prognostic factors of cancer progression, effectiveness of the treatment, recurrence
p. 339-347 of the original issue
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Address for correspondence:
630090, Rossiskaya Federatsiya,
g. Novosibirsk, pr-t. akad. Lavrenteva, 8,
Institut khimicheskoy biologii
i fundamentalnoy meditsinyi SO RAN,
Tsentr novyih meditsinskih tehnologiy,
tel.mob.: 7-913-753-0767,
e-mail: imai@mail.ru,
Maiborodin Igor Valentinovich
Information about the authors:
Maiborodin I.V. MD, professor, a leading researcher of the stem cell laboratory of FSBES "Institute of Chemical Biology and Fundamental Medicine", of SB of RAS.
Krasilnikov S.E. MD, professor of the oncology chair of SBEE HPE "Novosibirsk State Medical University".
Kozjakov A.E. A post-graduate student of the oncology chair of SBEE HPE "Novosibirsk State Medical University".
Babayants E.V. PhD, an applicant for Doctor’s degree of the oncology chair of SBEE HPE "Novosibirsk State Medical University".
Kulidzhanyan A.P. A post-graduate student of the oncology chair of SBEE HPE "Novosibirsk State Medical University".
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