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Year 2022 Vol. 30 No 5

SCIENTIFIC PUBLICATIONS

SUCHKOV S.G., ALEXANDROV D.A., NIKOLAEVTSEV V.A., SUCHKOV D.S., TOLSTOKOROV A.S. TOPCHIEV P.M., SKOROKHOD A.A.

THE ESTIMATION OF THE BLOOD SUPPLY AND VIABILITY OF BIOLOGICAL TISSUES USING A POTABLE CAPACITIVE SENSOR

Saratov State Medical University named after V.I. Razumovsky Ministry of Health of Russian Federation,
Saratov National Research State University named after N.G. Chernyshevsky,
Saratov, Russian Federation

Objective. The search for optimal time intervals for the use of a capacitive sensor and obtaining with its help universal normalized indicators of blood filling and tissue viability in the interests of disaster medicine and emergency surgery.
Methods. The fact of a significant difference in the dielectric permittivity of tissues not filled with blood and the dielectric permittivity of blood is used. Therefore, the level of blood filling of the tissue can be characterized by the value of the measured capacitance CT(t) of the electrode structure applied to the tissue. To study the effect of blood filling and the viability of biological tissues on the readings of a capacitive sensor, experiments were conducted on 20 male white laboratory rats weighing 200-250 g. In the first group of 10 animals, CT(t) indicators were examined on the thigh skin for 10 seconds with the results recorded every 5 seconds before the introduction of adrenaline and 5 minutes after its introduction. In the second group of 10 animals, CT(t) measurements were carried out on the thigh skin for 1 minute with the fixation of capacity values every 10 seconds to determine the universal normalized indicators of blood filling and viability of CN(t). The significance of the differences in paired measurements of absolute values of CT(t) was evaluated according to the Wilcoxon criterion. To determine the significance of the differences between the proposed normalized values of CN(t) in living and dead animals, the Student’s criterion was used.
Results. The device showed sufficient sensitivity to changes in blood filling of the skin in response to the introduction of adrenaline. The indicators of the capacitive sensor in live animals grow rapidly and statistically significantly within one minute of continuous measurement, unlike dead tissues, where the indicators do not change. It is established that the necessary and sufficient information is provided by the capacitance values at the tenth and twentieth seconds of measurement. The measurement results showed a significant variation in the absolute values of the sensor capacity in different animals, but a similar dynamics of the increase of these indicators under the same experimental conditions. These data made it possible to calculate universal normalized indicators for the practical use of a capacitive sensor.
Conclusion. The proposed compact autonomous capacitive sensor has prospects of application in emergency and vascular surgery for emergency assessment of blood filling and viability of tissues and organs of patients. Optimal time intervals and normalized indicators of performed measurements are established.

Keywords: biological tissue, blood supply, capacitive sensor, permittivity
p. 425-433 of the original issue
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Address for correspondence:
410012, Russian Federation,
Volga Federal District, Saratov Region, Saratov,
st. Bolshaya Kazachya 112,
Saratov State Medical University Named
after V.I. Razumovsky Ministry of Health of Russian Federation, Department of Surgery and Oncology,
tel. +7-987-823-06-09,
e-mail: denirov@bk.ru,
Aleksandrov Denis A.
Information about the authors:
Suchkov Sergei G., D (Phys & Math), Senior Researcher, Director of the Scientific and Technological Center «Micro- and Nanoelectronics» Saratov National Research State University named after N.G. Chernyshevsky, Saratov National Research State University, Saratov, Russian Federation.
http://orcid.org/0000-0001-9159-3515
Alexandrov Denis A., MD (Phys & Math), Professor, Professor of the Department of Surgery and Oncology, Saratov State Medical University named after V.I. Razumovsky Ministry of Health of Russian Federation, Saratov, Russian Federation.
http://orcid.org/0000-0001-5503-8354
Nikolaevtsev Victor A., PhD (Phys & Math), Associate Professor, Associate Professor of the Department of Micro- and Nanoelectronics on the basis of JSC «SPE «Contact», Leading Engineer of the STC «Micro- and Nanoelectronics» Saratov National Research State University named after N.G. Chernyshevsky, Saratov, Russian Federation.
http://orcid.org/0000-0002-1233-3983
Suchkov Dmitry S., PhD (Phys & Math), Deputy Director of the Research Institute of Mechanics and Physics, Saratov National Research State University named after N.G. Chernyshevsky, Saratov, Russian Federation.
http://orcid.org/0000-0003-4527-7874
Tolstokorov Alexander S., MD, Professor, Head of the Department of Surgery and Oncology, Saratov State Medical University Named after V.I. Razumovsky Ministry of Health of Russian Federation, Saratov, Russian Federation.
http://orcid.org/0000-0002-8541-5330
Topchiev Pavel M., Resident of the Department of Surgery and Oncology, Saratov State Medical University Named after V.I. Razumovsky Ministry of Health of Russian Federation, Saratov, Russian Federation.
http://orcid.org/0000-0002-7189-5396
Skorokhod Anatoly A., 3rd year Student of Saratov State Medical University Named after V.I. Razumovsky Ministry of Health of Russian Federation, Saratov, Russian Federation.
http://orcid.org/0000-0001-9071-6579
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