Novosti
|
This journal is indexed in Scopus |
|---|
Year 2013 Vol. 21 No 5
ONCOLOGY
V.V. KHAZIEV
THYROID CANCER IN THE STRUCTURE OF EUTHYROID SINGLE-NODULAR PATHOLOGY
SE "Institute of Endocrine Pathology Problems named after V.Y.Danilevsky of National Academy of Medical Sciences of the Ukraine", Kharkov,
The Ukraine
Objectives. To carry out a retrospective analysis of the thyroid cancer prevalence in patients operated on for thyroid nodular pathology.
Methods. To investigate the prevalence peculiarities of various forms of the single-nodular pathology and thyroid cancer during 1985-2010 yrs. 25000 patients with different forms of nodular pathology were selected and 5350 case-histories of patients with clinically and morphologically confirmed single-focal benign or malignant lesion without autoimmune process and disturbances of the thyroid function have been analyzed. The building of logarithmic trend line with the calculation of the coefficient of determination R2 (regression analysis) has been used to identify tendency data and prognostication.
Results. High frequency of thyroid cancer in euthyroid single-nodular pathology has been detected. Patients with the single-nodular goiter made up 87,33%, with the thyroid cancer – 12,67% (ratio 7:1). The overall ratio of male/female for the single-nodular goiter composed 1:11,73 and 1: 3,89 for thyroid cancer. A highly reliable tendency of increase in the proportion of males among patients with the single-nodular euthyroid goiters and thyroid cancer was revealed in the period of 1985-2010 yrs. Single colloidal structures (64,77%) and follicular adenomas (24,55%) dominated in the pathologic structure of benign single-nodular growth. Single-nodular malignant pathology was presented by papillary (65,19%) and follicular carcinomas (29,79%) in the majority of cases. Forms of thyroid cancer without damaging of the lymphatic system and distant metastases made up 76,84% summarily.
Conclusions. High frequency of thyroid cancer in patients with single-nodular pathology and the prevalence of “small” forms demonstrate the need to regard the presence of nodular growth as a cancer risk factor especially in men.
- Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA. 2006 May 10;295(18):2164–67.
- Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol. 2006 Jun;154(6):787–803.
- Larіn OS, Pan'kіv VІ, Selіvanenko MІ, Grachova OO. Analіz dіial'nostі endokrinologіchnoї sluzhbi Ukraїni u 2010 rotsі ta perspektivi rozvitku medichnoї dopomogi khvorim z endokrinnoiu patologієiu [Analysis of the endocrinology service of Ukraine in 2010 yr. and prospects of medical care development to the patients with endocrine disorders]. Mezhdunarod Endokr Zhurnal. 2011;35(3):10–18.
- Mel'nichenko GA, Troshina EA, Vanushko VE, Rumiantsev PO, Platonova NM, Kavtaradze SR. Spornye voprosy lecheniia differentsirovannogo raka shchitovidnoi zhelezy [Controversial issues of treatment of differentiated thyroid cancer]. Problem Endokrinol. 2008;54(2):14–22.
- Rumiantsev PO, Il'in AA, Rumiantseva UV, Saenko VA. Rak shchitovidnoi zhelezy. Sovremennye podkhody k diagnostike i lecheniiu [Current approaches to diagnosis and treatment]. Moscow, RF: GEOTAR¬Media, 2009. 448 p.
- Tuttle RM, Ball DW, Byrd D, Dilawari RA, Doherty GM, Duh QY, Ehya H, Farrar WB, Haddad RI, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey JC, Olson JA Jr, Parks L, Ridge JA, Shah JP, Sherman SI, Sturgeon C, Waguespack SG, Wang TN, Wirth LJ; Thyroid carcinoma. J Natl Compr Canc Netw. 2010 Nov;8(11):1228–74.
- Shaha AR. Controversies in the management of thyroid nodule. Laryngoscope. 2000 Feb;110(2 Pt 1):183–93.
- Gharib H, Papini E, Valcavi R, Baskin HJ, Crescenzi A, Dottorini ME, Duick DS, Guglielmi R, Hamilton CR Jr, Zeiger MA, Zini M; American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract. 2006 Jan-Feb(12)1:63–102.
- Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009 Nov;19(11):1167–214.
61002, Ukraina, g. Kharkov, ul. Artema, d. 10, GU Institut problem endokrinnoi patologii im. V. Ia. Danilevskogo Natsional'noi Akademii meditsinskikh nauk Ukrainy, otdelenie endokrinnoi 61002, Ukraina, g. Kharkov, ul. Artema, d. 10, GU Institut problem endokrinnoi patologii im. V. Ia. Danilevskogo Natsional'noi Akademii meditsinskikh nauk Ukrainy, otdelenie endokrinnoi khirurgii i ginekologii,
e-mail: khaziev@mail.ru,
Khaziev Vadim Vital'evich
Khaziev V.V. PhD, a head of the division of endocrine surgery and gynecology of SE "Institute of endocrine pathology named after V.J. Danilevsky of National Academy of Sciences of Ukraine".
Article in the .pdf format
